METHODS AND APPARATUS FOR TREATING THE PROSTATE

• US 20100286106A1
• Filed: 07/13/2008
• Published: 11/11/2010
• Est. Priority Date: 03/10/2008
• Status: Abandoned Application

• Current Assignee: Menachem Goren, Yigal Gat
• Original Assignee: Menachem Goren, Yigal Gat
• Inventors: Goren, Menachem, Gat, Yigal
• Application Number:
  US12/668,696
• Publication Number:
  US 20100286106A1
• Time in Patent Office: Days
• US Class Current: 514/178
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61K 31/277 having a ring, e.g. verapamil
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61M 2025/0681 Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters
• CPC Class Codes: A61P 13/08 of the prostate
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

Treating and/or preventing prostate problems and/or metastases, by selectively occluding various groin vessels and tools for selective occluding of various groin veins, including, for example, the deferential vein. Optionally providing anti-androgen treatment after such occluding.

Claims

1. A method for treating the prostate, comprising:

(a) positing the existence detecting abnormal cells that respond to an androgen in the prostate; and

(b) occluding an internal spermatic vein.

2. A method according to claim 1, wherein the abnormal cells are localized in the prostate.

3. A method according to claim 1, wherein the androgen comprises testosterone.

6. A method according to claim 1, further comprising administration of antiandrogen medication.

7. A method according to claim 6, wherein the antiandrogen medication is administered locally to the prostate.

8. A method according to claim 6, wherein the administration of antiandrogen follows the occlusion.

9. A method according to claim 1, wherein occlusion of an internal spermatic vein comprises occlusion a junction between the internal spermatic vein and a pampiniform plexus.

10. A method according to claim 1, further comprising application of at least one of chemotherapy, radiotherapy, brachytherapy, thermotherapy or cryotherapy.

4-5. -5. (canceled)

11. A method for treating metastases, comprising:

(a) detecting prostate cancer metastases; and

(b) reducing venous pressure in the prostate while blocking reflux from testicular veins subject to abnormally high pressure.

12. A method according to claim 11, wherein reducing pressure in the prostate comprises occluding a vein between the prostate and a pampiniform plexus.

13. A method according to claim 12, wherein the vein is a least one of a deferential vein or a vesicular plexus vein.

14. A method according to claim 11, wherein an abnormally high pressure is maintained in the internal spermatic veins.

15. A method according to claim 11, further comprising administration of antiandrogen medication.

16. A method according to claim 15, wherein the administration of antiandrogen follows the blocking.

17. A method according to claim 11, further comprising application of at least one of chemotherapy, radiotherapy, brachytherapy, thermotherapy or cryotherapy.

18. A method for a preventive treatment of the prostate, comprising:

(a) assessing a risk for development of prostate disorder; and

(b) responsive to the risk, preventing venous reflux to the prostate.

19. A method according to claim 18, wherein preventing venous reflux to the prostate comprises occluding an internal spermatic vein.

21. A method according to claim 18, wherein prostate disorder comprises one of BPH and cancer.

22. A method according to claim 18, wherein the assessing comprises assessing varicocele.

23. A method according to claim 22, wherein varicocele is assessed by testicular temperature.

24. A method according to claim 18, wherein assessing comprises determining at least one of PSA level, prostate size or venous anatomy.

20. (canceled)

25. An intravascular catheter configured to apply material sideways from a first vein into a second vein branching from the first vein, comprising:

(a) a tube having a lumen; and

(b) an orifice connecting the lumen and a longitudinal external side of the tube.

26. A catheter according to claim 25, wherein the connection is substantially perpendicular to the longitudinal external side of the tube.

27. A catheter according to claim 25, wherein the lumen is sealed at the distal end.

28. A catheter according to claim 27, wherein the orifice is sufficiently close to the sealed end to enable material in the lumen to deflect from the lumen via the orifice outside the lumen.

29. A catheter according to claim 25, further comprising at least one guiding element configured to support a positioning of the orifice in front of an opening of the second vein.

30. A catheter according to claim 29, wherein the at least one guiding element comprises a guide wire in the lumen movable into the orifice and the opening of the second vein.

31. A catheter according to claim 29, wherein the at least one guiding element comprises at least one radio opaque element located about the perimeter of the orifice.

32. A catheter according to claim 25, further comprising at least one expandable and retractable element capable of blocking material drainage along the outside of the catheter.

33. A catheter according to claim 32, wherein the expanded at least one element is configured to fixate the catheter to walls of the first vein.

34. A catheter according to claim 25, wherein the material comprises a sclerosant.

35. A catheter according to claim 25, wherein the material comprises a coil.

36-61. -61. (canceled)

62. Use of an anti-androgen composition for treatment of prostate cancer in patients with a blocked differential vein.

63. Use of a sclerosant for treatment of prostate cancer or BPH.

64. Use of an anti-androgen composition for treatment of prostate cancer by achieving a prostatic androgen level of less than 20% of a normal level.

65-67. -67. (canceled)