Method and Apparatus for Determining One or More Blood Parameters From Analog Electrical Signals
First Claim
1. ) An apparatus for obtaining physiological information from a subject the apparatus comprising:
- a) one or more light sources configured to apply partially or entirely coherent light to a target region of the subject to induce a light response signal from the illuminated target region;
b) a detection system including;
i) a first photodetector configured to detect the light response signal prevailing at a first location to generate a first photodetector analog electrical signal; and
ii) a second photodetector configured to detect the second light response signal prevailing at a second location to generate a second photodetector analog electrical signal, the second location being offset from the first location by an offset distance that is at least 0 5 mm and at most 2 cm;
c) an analog electronics assembly configured to generate, from the first and second analog electrical signals, a difference analog electrical signal that is indicative of a difference between the light response signal at the first location and light response signal at the second location;
d) a digitizer for digitizing the difference analog electrical signal to generate a digitized signal; and
e) a digital processing unit operative to receive and analyze the digitized signal to compute at least one physiological parameter of the subject.
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Abstract
Embodiments of the present invention relate to a system and method for in vivo measurement of blood parameters by processing analog electrical signals from a plurality of photodetectors. In some embodiments, it is possible to determine one or more blood parameters according to (i) a first electrical signal from a first detector and (ii) a second electrical signal from a second photodetector. A difference analog electrical signal is generated, indicative of a difference between the light response signal at the first location and light response signal at the second location, is generated. One or more blood parameters may be detected according to the difference analog electrical signal.
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Citations
23 Claims
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1. ) An apparatus for obtaining physiological information from a subject the apparatus comprising:
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a) one or more light sources configured to apply partially or entirely coherent light to a target region of the subject to induce a light response signal from the illuminated target region; b) a detection system including; i) a first photodetector configured to detect the light response signal prevailing at a first location to generate a first photodetector analog electrical signal; and ii) a second photodetector configured to detect the second light response signal prevailing at a second location to generate a second photodetector analog electrical signal, the second location being offset from the first location by an offset distance that is at least 0 5 mm and at most 2 cm; c) an analog electronics assembly configured to generate, from the first and second analog electrical signals, a difference analog electrical signal that is indicative of a difference between the light response signal at the first location and light response signal at the second location; d) a digitizer for digitizing the difference analog electrical signal to generate a digitized signal; and e) a digital processing unit operative to receive and analyze the digitized signal to compute at least one physiological parameter of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. ) A method for obtaining physiological information from a subject in accordance with a light field whose intensity varies according to location, the method comprising:
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a) applying partially or entirely coherent light to a target region of the subject to induce a light response signal from the illuminated target region which contributes to a location-dependent light field; b) detecting the light field prevailing at a first location to generate a first analog signal, the first analog signal including a DLS component of is indicative of a first dynamic light scattering (DLS) measurement; c) detecting the light field signal prevailing at a second location to generate a second analog signal including a DLS component that is indicative of a second dynamic light scattering (DLS) measurement a ratio and that is uncorrelated with the DLS component of the first analog signal; and d) processing the first and second analog signals to generate a processed analog signal including a DLS component that is indicative of a combination of the first and second dynamic scattering measurements, wherein the method is carried out so that a ratio between; i) a boosted DLS contribution ratio between a magnitude of the DLS component of the processed analog signal and the magnitude of the processed analog signal; and ii) at least one of a first DLS contribution ratio and a second DLS contribution ratio, is at least 10, and wherein; i) the first DLS contribution ratio is defined as a ratio between a magnitude of the DLS component of the first analog signal and the magnitude of the first analog signal; and ii) the second output ratio is defined as a ratio between a magnitude of the DLS component of the second analog signal and the magnitude of the second analog signal. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification