SYSTEMS AND METHODS FOR ANALYSIS AND TREATMENT OF A BODY LUMEN

• US 20100286531A1
• Filed: 05/20/2010
• Published: 11/11/2010
• Est. Priority Date: 09/30/2005
• Status: Abandoned Application

• Current Assignee: CorNova, Inc.
• Original Assignee: CorNova, Inc.
• Inventors: Ryan, S. Eric, Gambale, Richard, Tang, Jing
• Application Number:
  US12/784,482
• Publication Number:
  US 20100286531A1
• Time in Patent Office: Days
• US Class Current: 600/478
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body

Abstract

A system for analyzing a body lumen including a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end; at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit; a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm⁻¹ and about 10 cm⁻¹ when transmitted through a highly aqueous media; a controller system configured to calculate at least one of an extent, area, and volume of highly aqueous media based on the amount of absorption of the at least one primary radiation signal measured through the highly aqueous media by the spectrometer.

Claims

1. A system for analyzing a body lumen comprising:

a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end;

at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit;

a spectrometer connected to the at least one delivery waveguide and the at least one collection waveguide, the spectrometer configured to perform diffuse reflectance spectroscopy, wherein the spectrometer emits at least one primary radiation signal of a wavelength having an absorption coefficient of between about 8 cm<sup>−

1</sup> and about 10 cm<sup>−

1</sup> when transmitted through a highly aqueous media; and

a controller system configured to calculate at least one of an extent, area, and volume of highly aqueous media based on the amount of absorption of the at least one primary radiation signal measured through the highly aqueous media by the spectrometer.

2. The system of claim 1 wherein the at least one primary radiation signal comprises a wavelength between about 1350 nanometers and about 1850 nanometers.

3. The system of claim 2 wherein the at least one primary radiation signal further comprises a wavelength of about 1550 nanometers.

4. The system of claim 1 wherein the spectrometer is further configured to perform spectroscopy of at least one reference radiation signal of a wavelength having an absorption coefficient of less than about 8 cm⁻

1, and wherein the controller system is further configured to calculate a ratio of absorption between the amount of absorption of the at least one primary radiation signal and an amount of absorption of the at least one reference radiation signal measured through the highly aqueous media by the spectrometer in order to calculate the volume of highly aqueous media.

5. The system of claim 4 wherein the at least one reference radiation signal comprises a wavelength having an absorption coefficient of about 1 cm⁻

1 when transmitted through a highly aqueous media.

6. The system of claim 5 wherein the at least one primary radiation signal comprises a wavelength of about 1550 nanometers and the at least one reference radiation signal comprises a wavelength of about 1310 nanometers.

7. The system of claim 1 further comprising an angioplasty balloon disposed about a distal portion of the conduit.

8. The system of claim 7 wherein the transmission output of the at least one delivery waveguide and the transmission input of the at least one collection waveguide is located within the angioplasty balloon.

9. The system of claim 1 wherein the transmission output of the at the at least one delivery waveguide and the transmission input of the at least one collection waveguide are translatable along the longitudinal axis of the conduit.

10. The system of claim 1 wherein the transmission output of the at the at least one delivery waveguide and the transmission input of the at least one collection waveguide are radially translatable with respect to the conduit.

11. A method for treating or analyzing a body lumen, the method comprising:

inserting into a body lumen a catheter, the catheter comprising a flexible conduit that is elongated along a longitudinal axis, the flexible conduit having a proximal end and a distal end, at least one delivery waveguide and at least one collection waveguide extending along the flexible conduit, a transmission output of the at least one delivery waveguide and a transmission input of the at least one collection waveguide located along a distal portion of the conduit;

maneuvering the conduit into a designated region of the body lumen designated for treatment or analysis;

performing spectroscopy, wherein performing spectroscopy comprises;

transmitting at least one primary radiation signal through the at least one transmission output, wherein the wavelength of the at least one primary radiation signal has an absorption coefficient of between about 8 cm<sup>−

1</sup> and 10 cm<sup>−

1</sup> when transmitted through a highly aqueous media; and

collecting the at least one primary radiation signal at the at least one collection waveguide; and

measuring at least one of an extent, area, and volume of highly aqueous media about the at least one transmission output and the at least one transmission input with data obtained from the spectroscopy.

12. The method of claim 11 wherein the at least one primary radiation signal comprises a wavelength between about 1350 nanometers and about 1850 nanometers.

13. The method of claim 12 wherein the at least one primary radiation signal further comprises a wavelength of about 1550 nanometers.

14. The method of claim 11 wherein performing spectroscopy further comprises:

transmitting at least one reference radiation signal through the at least one transmission output, wherein the wavelength of the at least one reference radiation signal has an absorption coefficient of less then about 8 cm<sup>−

1</sup> when transmitted through a highly aqueous media; and

calculating a ratio of absorption between the amount of absorption of the at least one primary radiation signal and an amount of absorption of the at least one reference radiation signal measured through the highly aqueous media in order to calculate the volume of highly aqueous media.

15. The method of claim 14 wherein the at least one reference radiation signal comprises a wavelength having an absorption coefficient of about 1 cm⁻

1 when transmitted through a highly aqueous media.

16. The method claim 15 wherein the at least one primary radiation signal comprises a wavelength of about 1550 nanometers and the at least one reference radiation signal comprises a wavelength of about 1310 nanometers.

17. The method of claim 11 wherein the highly aqueous media comprises a saline solution.

18. The method of claim 11 wherein the highly aqueous media comprises blood.

19. The method of claim 11 wherein measuring the volume of highly aqueous media further comprises measuring the volume of expansion of an angioplasty catheter.

20. The method of claim 11 wherein measuring the volume of highly aqueous media further comprises measuring the width of the body lumen.

21. The method of claim 11 wherein during the performance of spectroscopy, at least one of the at least one transmission output and transmission input is positioned contiguously against the conduit.

22. The method of claim 11 wherein during the performance of spectroscopy, at least one of the at least one transmission output and transmission input is positioned adjacent to the body lumen.