DIAGNOSTIC METHODS AND SYSTEMS BASED ON URINE ANALYSIS

• US 20100286559A1
• Filed: 02/23/2010
• Published: 11/11/2010
• Est. Priority Date: 08/23/2007
• Status: Active Grant

• Current Assignee: Flowsense Ltd.
• Original Assignee: Flowsense Ltd.
• Inventors: Chimes, Stanley, Jackson, Martin Clive Henry, Paz, Ilan
• Granted Patent: US 8,827,924 B2
• Time in Patent Office: Days
• US Class Current: 600/581
• CPC Class Codes: A61B 10/007 for taking urine samples measuring urological functions A61B5/20; genital receptacles A61F5/451; urinals for bed-ridden persons A61G9/006
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/208 adapted to determine urine quantity, e.g. flow, volume
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/486 Bio-feedback A61B5/375 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: G01N 33/493 urine

Abstract

A diagnostic method and apparatus for detecting at least one change in a urinary parameter indicative of a body malfunction, the method comprising at least semi-continuously monitoring in real time at least one of a sodium level, an oxygen level, a potassium level, and combinations thereof in the urine of a catheterized patient; whereby at least one parameter is monitored so as to detect one or more changes in the at least one parameter to reflect at least one of a fluid state, an electrolyte balance, a kidney state, a kidney perfusion and an organ perfusion in the patient, indicative of the body malfunction in the patient, in which the monitoring is preferably performed through electrodes that are arranged perpendicularly to the flow of urine through a patient'"'"'s catheter system.

Claims

1. A monitoring apparatus for in-line monitoring of urine from a patient, the patient having a catheter inserted therein, the catheter having a distal portion extending outside of the patient, the apparatus comprising:

a catheter tube fluidly connected to said distal portion;

an electrode system fluidly connected to said catheter tube, said electrode system comprising a receiving connector for fluidly connecting to said catheter tube, and a chamber fluidly connected to said receiving connector, said chamber comprising at least one electrode arranged perpendicularly to a flow of urine through said chamber.

2. The apparatus of claim 1, comprising a plurality of electrodes arranged perpendicularly to the flow of urine in said chamber.

3. The apparatus of claim 2, wherein said electrodes are arranged to measure one or more of sodium, potassium, oxygen, pH or a combination thereof.

4. The apparatus of claim 3, wherein said catheter tube comprises a negative pressure tube for providing continuous flow of urine through said chamber.

5. The apparatus of claim 4, wherein said electrode system further comprises a measurement reader for determining a measurement of said one or more of sodium, potassium, oxygen, pH or a combination thereof.

6. The apparatus of claim 5, wherein said measurement reader further comprises a computational processor for processing said measurement.

7. The apparatus of claim 6, wherein said computation processor also processes said measurement according to a calibration reading.

8. The apparatus of claim 7, wherein said electrode system further comprises a color detector.

9. The apparatus of claim 8, wherein said electrode system further comprises a turbidity detector.

10. The apparatus of claim 9, wherein said electrode system further comprises a particle size detector.

11. A diagnostic method for detecting at least one change in a urinary parameter indicative of a body malfunction, the method comprising at least semi-continuously monitoring in real time at least one of a sodium level, an oxygen level, a potassium level, and combinations thereof in the urine of a catheterized patient;

whereby at least one parameter is monitored so as to detect one or more changes in the at least one parameter to reflect at least one of a fluid state, an electrolyte balance, a kidney state, a kidney perfusion and an organ perfusion in the patient, indicative of the body malfunction in the patient, in which the monitoring is preferably performed through electrodes that are arranged perpendicularly to the flow of urine through a patient'"'"'s catheter system, in line to said system.