COMPOSITE BIOMATERIAL FOR CONTROLLED RELEASE OF ACTIVE INGREDIENTS
First Claim
1. Composite biomaterial with local, controlled release of active ingredients, comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure which is introduced into the three-dimensional support structure and homogenously distributed in the support structure, wherein active ingredients are incorporated into the composite biomaterial via the matrix structure.
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Abstract
The present invention relates to a composite biomaterial and a process for producing a composite biomaterial with controlled release of active ingredients, comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure. The active ingredients are in this case incorporated into the composite biomaterial via the matrix structure, and the composite biomaterial is obtainable by introducing the matrix structure into the support structure. The active ingredients may in this case be incorporated for example adhesively, via specific binder molecules or via enzyme-labile linker molecules via the matrix structure into the composite biomaterial.
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Citations
17 Claims
- 1. Composite biomaterial with local, controlled release of active ingredients, comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure which is introduced into the three-dimensional support structure and homogenously distributed in the support structure, wherein active ingredients are incorporated into the composite biomaterial via the matrix structure.
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13. Process for producing a composite biomaterial comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure, comprising the following consecutive steps:
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a) separate provision of i) polymer-based support material and ii) polymer-based matrix material; b) hydrophilization of the support material; and c) introduction of the matrix material provided in step a) into the hydrophilized support material from step b) to produce a composite biomaterial with a support structure and a matrix structure. - View Dependent Claims (14)
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15. Method for treating degenerated or diseased tissue in a patient in need thereof, comprising the step of administering or implanting a composite biomaterial to said patient, said composite biomaterial having a local, controlled release of active ingredients, and comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure which is introduced into the three-dimensional support structure and homogenously distributed in the support structure, wherein active ingredients are incorporated into the composite biomaterial via the matrix structure.
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16. Method for treating cancer in a patient suffering from cancer, comprising the step of administering or implanting a composite biomaterial having a local, controlled release of active ingredients, and comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure which is introduced into the three-dimensional support structure and homogenously distributed in the support structure, wherein active ingredients are incorporated into the composite biomaterial via the matrix structure to said patient, and of the local delivering of chemotherapeutics released from said composite biomaterial in said patient.
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17. Method for cultivating cells in vitro, comprising the steps of providing a composite biomaterial having a local, controlled release of active ingredients, and comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure which is introduced into the three-dimensional support structure and homogenously distributed in the support structure, wherein active ingredients are incorporated into the composite biomaterial via the matrix structure, seeding said composite biomaterial with at least one cell or cell population, and cultivating the cells in the composite biomaterial under conditions that promote growth of said cells.
Specification