Drug-Loaded Fibers

• US 20100291182A1
• Filed: 11/17/2009
• Published: 11/18/2010
• Est. Priority Date: 01/21/2009
• Status: Abandoned Application

• Current Assignee: Arsenal Medical, Inc
• Original Assignee: Arsenal Medical, Inc
• Inventors: Marini, John, Pham, Quyhn, Palasis, Maria, Sharma, Upma
• Application Number:
  US12/620,334
• Publication Number:
  US 20100291182A1
• Time in Patent Office: Days
• US Class Current: 424/426
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/4468 having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
• CPC Class Codes: A61K 31/4535 containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 31/575 substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/0085 Brain, e.g. brain implants; Spinal cord
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: A61P 27/12 : for cataracts
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

Implants and methods for the delivery of a therapeutic agent to a target location within a patient'"'"'s body are disclosed. The implants include a fiber comprising a polymeric material and having a diameter of up to about twenty microns, and a first therapeutic agent within the fiber. The therapeutic agent is substantially in particulate form. The implants are of a variety of configurations, such as individual fibers, yarns, ropes, tubes, and patches.

Claims

1. An implant for the delivery of a therapeutic agent to a location within a patient'"'"'s body, comprising:

a fiber comprising a first polymeric material and having a diameter of up to about 20 microns, and

a first therapeutic agent within said fiber, wherein the amount of said therapeutic agent is greater than the solubility limit of said therapeutic agent in said first polymeric material.

2. The implant of claim 1, wherein said first therapeutic agent makes up at least about 20 weight percent of said fiber.

3. The implant of claim 1, wherein said first therapeutic agent makes up at least about 30 weight percent of said fiber.

4. The implant of claim 1, wherein said first therapeutic agent makes up at least about 40 weight percent of said fiber.

5. The implant of claim 1, wherein said fiber comprises an inner radial portion and an outer radial portion.

6. The implant of claim 5, wherein substantially all of said first therapeutic agent is located within said inner radial portion.

7. The implant of claim 6, further comprising a second therapeutic agent within said fiber.

8. The implant of claim 7, wherein substantially all of said second therapeutic agent is located within said outer radial portion.

9. The implant of claim 1, wherein said first polymeric material is bioabsorbable.

10. The implant of claim 5, further comprising a second polymeric material.

11. The implant of claim 10, wherein said inner radial portion comprises said first polymeric material and said outer radial portion comprises said second polymeric material, said first and second polymeric materials being different from one another.

12. The implant of claim 1, wherein said implant comprises at least one fiber formed into a yarn.

13. The implant of claim 12, wherein said implant comprises at least two yarns formed into a rope.

14. The implant of claim 13, wherein said at least two yarns each comprise a different therapeutic agent.

15. The implant of claim 13, further comprising a radiopaque band placed around at least one of said yarns.

16. The implant of claim 15, wherein said radiopaque band is bioabsorbable.

17. The implant of claim 1, wherein said implant comprises at least one fiber formed into a tube.

18. The implant of claim 1, wherein said implant comprises at least one fiber formed into a patch.

27. The implant of claim 15, wherein said radiopaque band is bioabsorbable.

19. An implant for the delivery of a therapeutic agent to a location within a patient'"'"'s body, comprising:

a fiber comprising a first polymeric material and having a diameter of up to about 20 microns, said fiber comprising an inner radial portion and an outer radial portion; and

a first therapeutic agent within said fiber, wherein substantially all of said first therapeutic agent is located within said inner radial portion, and the amount of said therapeutic agent is greater than the solubility limit of said therapeutic agent in said first polymeric material.

23. The implant of claim 19, wherein said implant comprises at least one fiber formed into a yarn.

28. The implant of claim 19, wherein said implant comprises at least one fiber formed into a tube.

29. The implant of claim 19, wherein said implant comprises at least one fiber formed into a patch.

20. The implant of claim 20, wherein said first therapeutic agent makes up at least about 20 weight percent of said fiber.

21. The implant of claim 20, wherein said first therapeutic agent makes up at least about 30 weight percent of said fiber.

22. The implant of claim 20, wherein said first therapeutic agent makes up at least about 40 weight percent of said fiber.

24. The implant of claim 20, wherein said implant comprises at least two yarns formed into a rope.

25. The implant of claim 24, wherein said at least two yarns each comprise a different therapeutic agent.

26. The implant of claim 24, further comprising a radiopaque band placed around at least one of said yarns.