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TUNABLE SUSTAINED RELEASE OF A SPARINGLY SOLUBLE HYDROPHOBIC THERAPEUTIC AGENT FROM A HYDROGEL MATRIX

  • US 20100291191A1
  • Filed: 05/21/2010
  • Published: 11/18/2010
  • Est. Priority Date: 04/25/2005
  • Status: Active Grant
First Claim
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1. A hydrogel matrix comprising an aqueous solution of methylcellulose or other water soluble hydrophobic cellulose derivative, in which particles of at least one selected size of at least one sparingly soluble hydrophobic agent are dispersed and solubilised, which is blended with an anionic polysaccharide or a derivative thereof to form the hydrogel matrix, the water solubility of the sparingly soluble hydrophobic agent being increased in the presence of the methylcellulose or other water soluble hydrophobic cellulose derivative, which together with the selected particle sizes determine the sustained release profile of the at least one sparingly soluble hydrophobic agent from the hydrogel matrix.

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