TUNABLE SUSTAINED RELEASE OF A SPARINGLY SOLUBLE HYDROPHOBIC THERAPEUTIC AGENT FROM A HYDROGEL MATRIX
First Claim
1. A hydrogel matrix comprising an aqueous solution of methylcellulose or other water soluble hydrophobic cellulose derivative, in which particles of at least one selected size of at least one sparingly soluble hydrophobic agent are dispersed and solubilised, which is blended with an anionic polysaccharide or a derivative thereof to form the hydrogel matrix, the water solubility of the sparingly soluble hydrophobic agent being increased in the presence of the methylcellulose or other water soluble hydrophobic cellulose derivative, which together with the selected particle sizes determine the sustained release profile of the at least one sparingly soluble hydrophobic agent from the hydrogel matrix.
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Abstract
The incorporation of polymeric excipients into an injectable hydrogel matrix, for example, methyl cellulose in the case of a hydrogel matrix comprising hyaluronan and methylcellulose (HAMC) has been found to increase the solubility of sparingly soluble hydrophobic drugs and tune their rate of release. The hydrogel matrix may also include other sparingly soluble hydrophobic food or cosmetic agents.
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Citations
24 Claims
- 1. A hydrogel matrix comprising an aqueous solution of methylcellulose or other water soluble hydrophobic cellulose derivative, in which particles of at least one selected size of at least one sparingly soluble hydrophobic agent are dispersed and solubilised, which is blended with an anionic polysaccharide or a derivative thereof to form the hydrogel matrix, the water solubility of the sparingly soluble hydrophobic agent being increased in the presence of the methylcellulose or other water soluble hydrophobic cellulose derivative, which together with the selected particle sizes determine the sustained release profile of the at least one sparingly soluble hydrophobic agent from the hydrogel matrix.
- 21. A hydrogel matrix comprising an aqueous solution of methylcellulose or other water soluble hydrophobic cellulose derivative, in which particles of at least one selected size of at least one sparingly soluble hydrophobic agent are dispersed and solubilised, the solubility of the sparingly soluble hydrophobic agent being increased in the presence of the methylcellulose or other water soluble hydrophobic cellulose derivative, which together with the selected particle sizes determine the sustained release profile of the at least one sparingly soluble hydrophobic agent from the hydrogel matrix.
Specification