RAPID DETECTION OF VOLATILE ORGANIC COMPOUNDS FOR IDENTIFICATION OF MYCOBACTERIUM TUBERCULOSIS IN A SAMPLE
First Claim
Patent Images
1. A method for identifying Mycobacterium tuberculosis bacteria in a sample, the method comprising:
- detecting one or more volatile organic compounds indicative of a presence of or response to treatment or resistance of the Mycobacterium tuberculosis bacteria in the sample, the one or more volatile organic compounds being selected from the group consisting of ethyl propionate, 1-pentanol, methyl valerate, 1-hexanol, ethyl valerate, methyl caproate, ethyl caproate, and any of the foregoing compounds in isotopically labeled form.
1 Assignment
0 Petitions
Accused Products
Abstract
In various embodiments, the invention relates to a method for identifying the presence of particular bacteria in a sample. The method includes collecting a sample that includes or has been exposed to the particular bacteria and detecting, in the sample, at least one volatile organic compound indicative of the presence of the bacteria.
42 Citations
25 Claims
-
1. A method for identifying Mycobacterium tuberculosis bacteria in a sample, the method comprising:
detecting one or more volatile organic compounds indicative of a presence of or response to treatment or resistance of the Mycobacterium tuberculosis bacteria in the sample, the one or more volatile organic compounds being selected from the group consisting of ethyl propionate, 1-pentanol, methyl valerate, 1-hexanol, ethyl valerate, methyl caproate, ethyl caproate, and any of the foregoing compounds in isotopically labeled form. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
15. A method for identifying Mycobacterium tuberculosis bacteria in a sample, the method comprising:
-
a. culturing a sample in a media comprising an alkali metal propionate, an alkali metal pentanoate, an alkali metal hexanoate, cholesterol, or any of the foregoing compounds in isotopically labeled form; and b. detecting one or more volatile organic compounds indicative of a presence of or response to treatment or resistance of the Mycobacterium tuberculosis bacteria from the cultured sample, the one or more volatile organic compounds being selected from the group consisting of ethyl propionate, 1-pentanol, methyl valerate, 1-hexanol, ethyl valerate, methyl caproate, ethyl caproate, and any of the foregoing compounds in isotopically labeled form. - View Dependent Claims (16, 17, 18, 19, 20, 21)
-
-
22. A method for identifying Mycobacterium tuberculosis bacteria in a sample, the method comprising:
-
a. collecting a sample suspected of comprising Mycobacterium tuberculosis bacteria; b. culturing the sample using a media comprising at least two compounds selected from the group consisting of cholesterol, sodium propionate, sodium pentanoate, sodium hexanoate, and any of the foregoing compounds in isotopically labeled form; and c. detecting one or more volatile organic compounds associated with Mycobacterium tuberculosis metabolism and indicative of a presence of or response to treatment or resistance of the Mycobacterium tuberculosis bacteria in the cultured sample.
-
-
23. A device for identifying Mycobacterium tuberculosis bacteria in a sample, the device comprising:
-
a. an input for receiving a sample suspected of comprising Mycobacterium tuberculosis bacteria; and b. a means for detecting one or more volatile organic compounds indicative of a presence of or response to treatment or resistance of the Mycobacterium tuberculosis bacteria in the sample, the one or more volatile organic compounds being selected from the group consisting of ethyl propionate, 1-pentanol, methyl valerate, 1-hexanol, ethyl valerate, methyl caproate, ethyl caproate, and any of the foregoing compounds in isotopically labeled form. - View Dependent Claims (24, 25)
-
Specification