PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS
First Claim
1. A process for preparing a methacrylic acid or a methacrylic ester, comprisingIA) preparing a 3-hydroxyisobutyric acid by a process comprising bringing a cell which is genetically modified in comparison with a wild type of the cell, wherein the cell is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoate comprising 3 hydroxyisobutyric acid, into contact with a nutrient medium comprising, as carbon source, carbohydrate, glycerol, carbon dioxide, methane, methanol, L-valine or L-glutamate under a condition wherein a 3-hydroxyisobutyric acid or polyhydroxyalkanoate comprising 3-hydroxyisobutyric acid is obtained from the carbon source, optionally isolating the 3-hydroxyisobutyric acid from the nutrient medium and optionally neutralizing the 3-hydroxyisobutyric acid, andIB) dehydrating the 3-hydroxyisobutyric acid, forming a methacrylic acid and optionally esterifying the methacrylic acid.
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Abstract
The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of
- IA) preparation of 3-hydroxyisobutyric acid by a process comprising the process step of bringing a cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid in comparison with its wild type, into contact with a nutrient medium comprising, as carbon source, carbohydrates, glycerol, carbon dioxide, methanol, L-valine or L-glutamate under conditions under which 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid are formed from the carbon source, if appropriate, isolation of the 3-hydroxyisobutyric acid from the nutrient medium and also, if appropriate, neutralization of the 3-hydroxyisobutyric acid,
- IB) dehydration of the 3-hydroxyisobutyric acid with formation of methacrylic acid and also, where appropriate, esterification methacrylic acid.
The invention also relates to a process for the preparation of polymethacrylic acid or polymethacrylic esters.
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Citations
27 Claims
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1. A process for preparing a methacrylic acid or a methacrylic ester, comprising
IA) preparing a 3-hydroxyisobutyric acid by a process comprising bringing a cell which is genetically modified in comparison with a wild type of the cell, wherein the cell is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoate comprising 3 hydroxyisobutyric acid, into contact with a nutrient medium comprising, as carbon source, carbohydrate, glycerol, carbon dioxide, methane, methanol, L-valine or L-glutamate under a condition wherein a 3-hydroxyisobutyric acid or polyhydroxyalkanoate comprising 3-hydroxyisobutyric acid is obtained from the carbon source, optionally isolating the 3-hydroxyisobutyric acid from the nutrient medium and optionally neutralizing the 3-hydroxyisobutyric acid, and IB) dehydrating the 3-hydroxyisobutyric acid, forming a methacrylic acid and optionally esterifying the methacrylic acid.
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26. (canceled)
Specification