SUSTAINED DELIVERY OF EXENATIDE AND OTHER PEPTIDES
First Claim
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1. A method of manufacturing an implantable device, wherein the implantable device can deliver a therapeutic polypeptide agent to a subject, and the release of the therapeutic polypeptide agent from the implantable device can be modulated by varying the components or the amounts of the components of the implantable device, the method comprising:
- a) mixing one or more polymerizable monomeric substances;
b) adding one or more substances selected from the group consisting of;
an excipient, a wetting agent, a non-ionic surfactant, an organic solvent, an alcohol, a reducing agent, an oxidizing agent and an aqueous solvent; and
c) subjecting the mixture to conditions that cause the one or more polymerizable monomeric substances to polymerize in the presence of the one or more components,thereby forming the implantable device.
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Abstract
Described herein are implantable devices, formulations and methods of making implantable devices for the release of a polypeptide from an implantable device, and methods of use thereof.
81 Citations
21 Claims
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1. A method of manufacturing an implantable device, wherein the implantable device can deliver a therapeutic polypeptide agent to a subject, and the release of the therapeutic polypeptide agent from the implantable device can be modulated by varying the components or the amounts of the components of the implantable device, the method comprising:
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a) mixing one or more polymerizable monomeric substances; b) adding one or more substances selected from the group consisting of; an excipient, a wetting agent, a non-ionic surfactant, an organic solvent, an alcohol, a reducing agent, an oxidizing agent and an aqueous solvent; and c) subjecting the mixture to conditions that cause the one or more polymerizable monomeric substances to polymerize in the presence of the one or more components, thereby forming the implantable device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of manufacturing an implantable device comprising:
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mixing one or more polymerizable monomeric substances and a release agent to form a mixture; and polymerizing the polymerizable monomeric substances to form the implantable device. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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Specification