IMPROVED THERAPEUTIC METHODS AND COMPOSITIONS COMPRISING CHROMAN RING COMPOUNDS
First Claim
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1. A method for treating a cancer patient wherein the patient comprises a Arg, p73, NOXA or FOXO1 positive cancer the method comprising administering an effective amount of a chroman ring derivavtives compound.
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Abstract
The instant invention concerns chroman ring derivative compounds such as vitamin E derivatives and methods for their use. In certain aspects, methods for treating subjects comprising Arg, JNK, p73, NOXA or FOXO1 positive cancers are provided. In still further aspects, methods for treating cell proliferative disease such as cancer by administration of a chroman ring compound in conjunction with a P13 or Akt kinase inhibitor are described.
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Citations
50 Claims
- 1. A method for treating a cancer patient wherein the patient comprises a Arg, p73, NOXA or FOXO1 positive cancer the method comprising administering an effective amount of a chroman ring derivavtives compound.
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4. (canceled)
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6. (canceled)
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12-15. -15. (canceled)
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17. A method for treating a cancer patient comprising:
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(i) obtaining or having a sample from the patient comprising proteins or nucleic acids from a cancer cell; (ii) determining whether the cancer cell expresses a Arg, p73, NOXA or FOXO1 gene; and (iii) treating the patient with an effective amount of a chroman ring derivative compound or another anti cancer therapy depending upon whether the cancer cell expresses a Arg, p73, NOXA or FOXO1 gene. - View Dependent Claims (18)
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19-42. -42. (canceled)
- 43. A method for treating a patient with a hyperproliferative disease comprising administering to the patient an effective amount of a chroman ring compound in combination with an Akt or PI3 kinase inhibitor.
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45-48. -48. (canceled)
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50-57. -57. (canceled)
Specification