TREATMENT OF ASPIRIN RESISTANCE WITH BETAINE AND/OR BETAINE ENRICHED MOLASSES
First Claim
1. A method of treating a human having a condition or being at risk for a condition selected from the group consisting of:
- (a) high levels of urinary and/or blood levels of 11-dehydro thromboxane B2 after being administered one or more antiplatelet compounds selected from the group consisting of aspirin, aspirin derivatives and combinations thereof;
(b) high levels of platelet and/or blood aggregation after being administered one or more antiplatelet compounds selected from the group consisting of aspirin, aspirin derivatives and combinations thereof;
(c) aspirin resistance;
(d) poor response to aspirin;
(e) resistance to at least two compounds selected from the group consisting of aspirin, clopidogrel, thienopyridines, and combinations thereof;
(f) resistance to aspirin, clopidogrel, or thienopyridines, who suffers or who is at risk of suffering of cardiovascular diseases, cerebrovascular diseases, or combinations thereof, while being treated by one or more of said compounds;
(g) cardiovascular diseases, cerebrovascular diseases, or combinations thereof who is aspirin resistant;
(h) thromboembolic disorders, ischemic disorders, or combinations thereof, who is resistant to aspirin, clopidogrel, or thienopyridines;
(i) thromboembolic disorders, in which an increase in thromboxane formation cannot be prevented by conventional dose rates of aspirin;
(j) reperfusion damage/ischemia, myocardial infarction, thrombolysis, tumours, stroke or balloon dilatation; and
(k) a disease requiring the administration of aspirin, in which an increase in thromboxane formation cannot be prevented by conventional dose rates of aspirin, said method comprising;
administering to said human a therapeutically effective amount of a betaine, a betaine enriched molasses, or a combination thereof.
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Accused Products
Abstract
Use of glycine betaine as therapeutically active ingredient for the preparation of a medicament and/or a nutritional product and/or a dietary supplement for treating human resistant to a compound selected from the group consisting of aspirin, clopidogrel, thienopyridines and combinations thereof, who suffers from a disease requiring the administration of a compound selected from the group consisting of aspirin, clopidogrel, thienopyridines and combinations thereof, or who is at risk of suffering of said disease, whereby the medicament comprises an effective amount of glycine betaine for decreasing by at least 10%, advantageously at least 20% the resistance of said patient to said compound selected from the group consisting of aspirin, clopidogrel, thienopyridines and combinations thereof
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Citations
23 Claims
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1. A method of treating a human having a condition or being at risk for a condition selected from the group consisting of:
- (a) high levels of urinary and/or blood levels of 11-dehydro thromboxane B2 after being administered one or more antiplatelet compounds selected from the group consisting of aspirin, aspirin derivatives and combinations thereof;
(b) high levels of platelet and/or blood aggregation after being administered one or more antiplatelet compounds selected from the group consisting of aspirin, aspirin derivatives and combinations thereof;
(c) aspirin resistance;
(d) poor response to aspirin;
(e) resistance to at least two compounds selected from the group consisting of aspirin, clopidogrel, thienopyridines, and combinations thereof;
(f) resistance to aspirin, clopidogrel, or thienopyridines, who suffers or who is at risk of suffering of cardiovascular diseases, cerebrovascular diseases, or combinations thereof, while being treated by one or more of said compounds;
(g) cardiovascular diseases, cerebrovascular diseases, or combinations thereof who is aspirin resistant;
(h) thromboembolic disorders, ischemic disorders, or combinations thereof, who is resistant to aspirin, clopidogrel, or thienopyridines;
(i) thromboembolic disorders, in which an increase in thromboxane formation cannot be prevented by conventional dose rates of aspirin;
(j) reperfusion damage/ischemia, myocardial infarction, thrombolysis, tumours, stroke or balloon dilatation; and
(k) a disease requiring the administration of aspirin, in which an increase in thromboxane formation cannot be prevented by conventional dose rates of aspirin, said method comprising;administering to said human a therapeutically effective amount of a betaine, a betaine enriched molasses, or a combination thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- (a) high levels of urinary and/or blood levels of 11-dehydro thromboxane B2 after being administered one or more antiplatelet compounds selected from the group consisting of aspirin, aspirin derivatives and combinations thereof;
- 10. A betaine enriched molasses comprising between 10% and 95% of betaine on a dry matter basis for the fabrication of a nutritional product.
Specification