METHOD AND DEVICE FOR SUBSTANCE MEASUREMENT
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Abstract
Embodiments of the present disclosure present systems, devices and methods for ISF glucose monitoring that more accurately reflects the blood glucose levels by introducing a treatment element allowing stable and accurate prediction of blood glucose levels based measured glucose levels from interstitial fluid.
54 Citations
88 Claims
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1-55. -55. (canceled)
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56. An apparatus for measuring an interstitial fluid (“
- ISF”
) in a tissue, comprising;a sensor arranged to be in fluid communication with ISF during use of the apparatus for measuring a level of a substance; a treatment element inserted to or otherwise in contact with tissue in which said sensor is arranged and/or tissue adjacent thereto; and a processor capable of communicating with said sensor and said treatment element, wherein said processor induces activity of said treatment element in relation to said sensor measurements of said substance. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
- ISF”
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73. A method for monitoring a substance in an interstitial fluid (“
- ISF”
), the method comprising the steps of;placing a sensor in a fluid communicative position relative to the ISF in a tissue; measuring a level of the substance in the ISF with said sensor; and treating the tissue with a treatment element to increase accuracy of measurement of the substance in the ISF relative to a blood level of the substance; wherein said treating is performed in relation to said sensor measurements of said substance. - View Dependent Claims (74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85)
- ISF”
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86. A method for monitoring a substance in an interstitial fluid (“
- ISF”
), comprising;placing a sensor in a fluid communicative position relative to the ISF in a tissue; measuring a level of a substance in the ISF with said sensor; and treating the tissue with a treatment element to reduce the delay between the measurement of the substance in the ISF relative to a blood level of the substance, wherein said treating is performed in relation to said measuring.
- ISF”
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87. A method for monitoring a substance in an interstitial fluid (“
- ISF”
), comprising;placing a sensor in a fluid communicative position relative to the ISF in a tissue; measuring a level of a substance in the ISF with said sensor; and treating the tissue with a treatment element to reduce calibration period for the measurement of the substance in the ISF relative to a blood level of the substance, wherein said treating is performed in relation to said measuring and/or enable to calibrate at high rate of substance level change in the blood
- ISF”
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88. A method for monitoring a substance in an interstitial fluid (“
- ISF”
), comprising;placing a sensor in a fluid communicative position relative to the ISF in a tissue; measuring a level of a substance in the ISF with said sensor; and treating the tissue with a treatment element to reduce the variability of the transport coefficients governing the transport of the substance between the ISF compartment and the blood compartment.
- ISF”
Specification