SEIZURE FORECASTING, MICROSEIZURE PRECURSOR EVENTS, AND RELATED THERAPEUTIC METHODS AND DEVICES
First Claim
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1. A therapeutic method including monitoring microseizures within neural microdomains in the brain.
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Abstract
A multiscale recording and stimulation system for identifying and responding to epileptiform activity. The system includes the use of microelectrode arrays (e.g., 10-100 micron electrodes with 100-500 micron spacing) to monitor iEEG activity of submillimeter regions or islands in the epileptogenic zone of brain tissue (e.g., independent microdomains in the range of 100-1000 micron diameter).
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Citations
17 Claims
- 1. A therapeutic method including monitoring microseizures within neural microdomains in the brain.
- 13. A passive recording and stimulation-response multiscale electrophysiology method, including monitoring microseizures in microdomain structures, for identifying epileptic brain, periods of increased seizure probability, and therapeutic intelligent control stimulation to prevent and/or abort seizures.
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