Meibomian Gland Intraductal Diagnostic and Treatment Methods

• US 20100292630A1
• Filed: 11/13/2008
• Published: 11/18/2010
• Est. Priority Date: 11/13/2007
• Status: Active Grant

• Current Assignee: MGD Innovations, Inc.
• Original Assignee: MGD Innovations, LLC
• Inventors: Maskin, Steven L.
• Granted Patent: US 10,159,599 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00709 Instruments for removing foreign bodies for removal of intra-ocular material A61F9/00736

Abstract

A method is provided for treating a meibomian gland of an eyelid of a patient. In a particular embodiment, an obstruction in a meibomian gland and the orifice thereof can be alleviated; in another, a substance can be injected thereinto; in yet another, the gland can be aspirated. The method includes the step of inserting an elongated probe into a meibomian gland via an orifice thereinto. In some embodiments the probe can have a longitudinal lumen therethrough, with at least one distal hole through the probe wall in fluid communication with the lumen. The lumen can be used in concert with a source of suction for removing debris from the meibomian gland, and/or with a source of a fluid and pumping means, for injecting a substance into the meibomian gland.

Claims

1. A method for treating a meibomian gland of an eyelid of a patient comprising:

inserting a distal end of an elongated probe into a meibomian gland of an eyelid of a patient via an orifice thereinto.

2. The method recited in claim 1, wherein the probe has a longitudinal lumen extending therealong defined by a probe wall and a distal hole through the probe wall in fluid communication with the lumen, the distal hole positioned in the probe distal end.

3. The method recited in claim 2, further comprising applying suction to the probe lumen, for aspirating debris from the meibomian gland into the probe lumen.

4. The method recited in claim 2, further comprising injecting a fluid into the meibomian gland from the probe lumen and out through the distal hole, the fluid comprising a desired medication.

5. The method recited in claim 4, further comprising a pump element for performing the fluid injection.

6. The method recited in claim 4, wherein the desired medication includes a growth-inhibiting agent.

7. The method recited in claim 6, wherein the growth-inhibiting agent includes at least one of a fibrous tissue growth-inhibiting agent and a vascular tissue growth inhibiting agent.

8. The method recited in claim 2, wherein the distal hole comprises a plurality of distal holes.

9. The method recited in claim 1, further comprising, prior to inserting the probe:

supporting the probe with an apparatus comprising;

a base;

an articulated arm affixed to the base;

a clamp affixed to the arm positionable in approximate alignment with an eye of the patient and adapted for releasably supporting the probe; and

visualization optics affixed to the base on an opposite side of the probe from the patient; and

visualizing the patient eye through the visualization optics.

10. The method recited in claim 1, further comprising, prior to inserting the probe:

supporting the probe with an apparatus comprising;

a base;

an arm affixed to the base;

a probe support affixed to the arm, positionable in approximate alignment with the patient meibomian gland orifice, and adapted for movably and releasably supporting the probe;

a motion-producing element affixed to the base in operative communication with the probe support, adapted for causing substantially linear movement by the probe; and

visualization optics affixed to the base on an opposite side of the probe from the patient; and

visualizing the patient eye through the visualization optics; and

wherein;

inserting the probe comprises;

aligning a distal tip of the probe with a target meibomian gland orifice; and

activating the motion-producing element to impel the probe into the meibomian gland via the orifice.

11. The method recited in claim 2, wherein:

the probe lumen comprises a first lumen and a second lumen;

the distal hole comprises a first distal hole in fluid communication with the first lumen and a second distal hole in fluid communication with the second lumen;

the suction is applied to the first lumen; and

further comprising injecting a fluid into the meibomian gland from the second lumen and out through the second distal hole, the fluid comprising a desired medication.

12. The method recited in claim 2, wherein the probe has an obstruction-removing element adjacent the probe distal end adapted for dislodging debris from the meibomian gland, and the method further comprises moving the obstruction-removing element within the meibomian gland to dislodge debris from the meibomian gland.

13. The method recited in claim 12, wherein the obstruction-removing element comprises a heating element.

14. The method recited in claim 12, wherein the obstruction-removing element comprises the probe distal end having an abrasive surface for exfoliating the meibomian gland.

15. The method recited in claim 12, wherein the obstruction-removing element comprises a router articulated at a distal end, and further comprising, following inserting the probe distal end, opening the router and moving the probe in a proximal direction, for scraping the meibomian gland.

16. The method recited in claim 2, wherein the probe has an elongated element positioned at least partially within the probe lumen and movable relative thereto to protrude from the probe distal end, the method further comprising moving the elongated element in a distal direction so that a distal portion of the elongated element protrudes from the probe distal end.

17. The method recited in claim 16, wherein the elongated element comprises a distal tip having a diameter greater than a diameter proximal thereof for assisting in obstruction removal.

18. The method recited in claim 16, wherein:

the probe lumen comprises a first lumen and a second lumen;

the distal hole comprises a first distal hole in fluid communication with the first lumen and a second distal hole in fluid communication with the second lumen; and

the elongated element is positioned within the first lumen; and

further comprising;

applying suction to the second lumen, for aspirating debris from the meibomian gland.

19. The method recited in claim 16, further comprising releasing a medication-delivery element into the meibomian gland from adjacent the probe distal end.

20. The method recited in claim 16, further comprising positioning a structural support within the meibomian gland adjacent the orifice, for assisting the retaining the orifice in an unobstructed condition.

21. The method recited in claim 20, wherein:

the structural support comprises a compressible, substantially toroidal element; and

the elongated element comprises a gripper operable from external the meibomian gland adapted for releasably holding the toroidal element in a compressed condition, a release of the toroidal element from the gripper permitting the toroidal element to expand and assist in holding the orifice open.

22. The method recited in claim 1, wherein none of thermal energy, electromagnetic energy, and other radiation and applied proximate to the distal end during insertion into the meibomian gland.

23. The method recited in claim 22, further comprising applying at least one of thermal and electromagnetic energy proximate to the distal end after insertion into the meibomian gland.

24. The method recited in claim 1, further comprising removing the distal end of the elongated probe from the meibomian gland and subsequently inserting into the meibomian gland a wider distal end.

25. The method recited in claim 1, further comprising removing the distal end of the elongated probe from the meibomian gland and subsequently inserting into the meibomian gland a longer distal end.

26. A device for treating a meibomian gland of an eyelid of a patient comprising:

a probe having an elongated distal end with an outer diameter of approximately 100 μ

m or less and a length of approximately 6 mm or less.

27. The device recited in claim 26, wherein the length of the elongated distal end is between approximately 2 mm and approximately 6 mm.

28. The device recited in claim 27, wherein the length of the elongated distal end is adjustable in fixed increments between approximately 2 mm and approximately 6 mm.

29. The device recited in claim 26, wherein the elongated distal end is fixedly secured to a body of the probe.

30. The device recited in claim 26, wherein the elongated distal end is extendable from the body of the probe.