Targeted drug delivery device and method

• US 20100292641A1
• Filed: 09/16/2009
• Published: 11/18/2010
• Est. Priority Date: 05/15/2009
• Status: Abandoned Application

• Current Assignee: Bandula Wijay, Nandhika Wijay
• Original Assignee: Bandula Wijay, Nandhika Wijay
• Inventors: Wijay, Nandhika, Wijay, Bandula
• Application Number:
  US12/586,033
• Publication Number:
  US 20100292641A1
• Time in Patent Office: Days
• US Class Current: 604/103.02
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 2025/1097 with perfusion means for enabling blood circulation only while the balloon is in an inflated state, e.g. temporary by-pass within balloon
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

A catheter described is a balloon angioplasty catheter either of Over the Wire design or the Rapid Exchange design and has an expansible sleeve over the balloon. The expansible sleeve is porous and is able to absorb large quantities of fluid and fluids containing anti-proliferative drugs or other bioactive agents. The porous sleeve also expands along with the balloon when the balloon is inflated making the porous sleeve in contact with the inner wall of the affected artery or body cavity. The pressure in the balloon can be increased or pulsed, using a piezoelectric transducer, to enhance the flow of the drug from the porous membrane into the vessel wall. The porous membrane can be left in contact for an extended time periods as the catheter contains an extra lumen to provide blood perfusion distal to the balloon. For those lesions necessitating extended drug delivery an additional lumen is provided to supply additional medicines to the lesions. As the drug(s) are passed into the tissue in way of squeezing the porous membrane, needles and the concept of diffusion are not used to deliver the drug and blood flow is not interrupted during drug delivery.

Claims

1. A catheter for a patient conduit or cavity having a wall, comprising:

an elongated body comprising at least one lumen;

a balloon in fluid communication with said lumen;

a discrete covering capable of storing at least one drug that is mounted over said balloon and said covering selectively releasing said drug when compressed against the wall of the conduit or cavity due to balloon inflation through said lumen.

2. The catheter of claim 1, wherein:

said covering has shape memory.

3. The catheter of claim 1, wherein:

said covering is porous.

4. The catheter of claim 1, wherein:

said covering retains said drug in its pore structure.

5. The catheter of claim 4, wherein:

said covering is loaded with said drug by immersion.

6. The catheter of claim 1, wherein:

said covering is reusable after removal for application of additional drug prior to reinsertion.

7. The catheter of claim 1, wherein:

said covering is secured to said balloon or said body.

8. The catheter of claim 1, wherein:

said at least one lumen comprises a balloon lumen for selective balloon inflation and a bypass lumen to allow flow past the balloon when against a wall.

9. The catheter of claim 8, wherein:

said bypass lumen extends the substantial length of said body and through said balloon and has at least one inlet port proximally of said balloon and at least one discharge port distally of said balloon.

10. The catheter of claim 9, wherein:

said inlet port is shielded to allow a distally advancing guide wire to pass over said inlet port.

11. The catheter of claim 10, wherein:

said shielding comprises a portion of said bypass lumen wall pushed in on an end closer to said balloon.

12. The catheter of claim 8, wherein:

said balloon and said bypass lumens are either coaxial or side by side.

13. The catheter of claim 8, further comprising:

a drug perfusion lumen through said body to reach said covering to allow delivery of drug to said covering when said covering is in said conduit or cavity.

14. The catheter of claim 13, wherein:

said drug perfusion lumen extends through said balloon.

15. The catheter of claim 1, wherein:

a piezoelectric device in said balloon to vibrate the fluid in said balloon for enhanced delivery of drug from said covering.

16. The catheter of claim 1, further comprising:

a drug perfusion lumen through said body to reach said covering to allow delivery of drug to said covering when said covering is in said conduit or cavity.

17. A catheter for a patient conduit or cavity having a wall, comprising:

an elongated body comprising a balloon lumen extending to a balloon located near a distal end of said body and a bypass lumen;

a balloon in fluid communication with said balloon lumen;

said bypass lumen comprising at least one shielded inlet located proximally to said balloon.

18. The catheter of claim 17, wherein:

said shielding comprises a portion of said bypass lumen wall pushed in on an end closer to said balloon.

19. The catheter of claim 17, wherein:

said at least one inlet comprises a plurality of inlets.

20. The catheter of claim 17, further comprising:

a guide wire;

said bypass lumen extending the substantial length of said body;

said shielding deflecting a guide wire that advanced distally toward said balloon and over said inlet away from said inlet.

21. The catheter of claim 20, further comprising:

a discrete covering capable of storing at least one drug that is mounted over said balloon and said covering selectively releasing said drug when compressed against the wall of the conduit or cavity due to balloon inflation through said balloon lumen.