Glucose Testing Device And Strips For Same

• US 20100294660A1
• Filed: 03/12/2010
• Published: 11/25/2010
• Est. Priority Date: 03/13/2009
• Status: Abandoned Application

• Current Assignee: Tyson Bioresearch Inc.
• Original Assignee: Tyson Bioresearch Inc.
• Inventors: Chen, Chia Jung, Yang, Yi-Chi, Tsai, Wen Hai, Yeh, Jih-Hsin, Lin, Hung Chih, Chang, Keng Hao, Wang, Shiow-Chen
• Application Number:
  US12/722,567
• Publication Number:
  US 20100294660A1
• Time in Patent Office: Days
• US Class Current: 204/403.14
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 2035/00742 Type of codes
• CPC Class Codes: G01N 2035/00831 identification of the sample, e.g. patient identity, place of sampling
• CPC Class Codes: G01N 2035/00851 process control parameters
• CPC Class Codes: G01N 33/48771 Coding of information, e.g. calibration data, lot number

Abstract

The present invention provides an electrochemical biosensor. The biosensor includes a substrate; a metal layer disposed on the substrate, wherein a first end of the metal layer is formed with a reaction region by a working electrode and a reference electrode provided on the metal layer, the reaction region is applied with an enzyme so that an electrical response is generated when the enzyme and a test sample form a chemical reaction, and a second end of the metal layer is provided with an integrated information unit to provide both test sample information and coding information.

Claims

1. An electrochemical biosensor, comprising:

a substrate;

a metal layer disposed on said substrate, wherein a first end of said metal layer is formed with a reaction region by a working electrode and a reference electrode provided on said metal layer, said reaction region is applied with an enzyme so that an electrical response is generated when said enzyme and a test sample form a chemical reaction, and a second end of said metal layer is provided with an integrated information unit to provide both coding information about said biosensor and said electrical response,

wherein said integrated information unit is provided with a plurality of digital on and off points capable of generating signals corresponding to said coding information and said electrical response.

2. The biosensor of claim 1, wherein said integrated information unit is formed by cutting on said second end of said metal layer so as to create different resistances.

3. The biosensor of claim 2, wherein said cutting process can be a laser cutting process.

4. The biosensor of claim 1, wherein each of said plurality of digital on and off points can be enabled by providing an electrical connection therethrough.

5. The biosensor of claim 4, wherein said plurality of digital on and off points can be implemented through a general purpose input/output (GPIO) connection.

6. The biosensor of claim 1, wherein said coding information is calibration information.

7. The biosensor of claim 1, wherein said integrated information unit is provided on a conductive film covering at least said second end of said metal layer.

8. The biosensor of claim 7, wherein said conductive film may be an Indium Tin Oxide (ITO) conductive film, an Indium Zin Oxide (IZO) conductive film, or any equivalent thereof.

9. The biosensor of claim 1, wherein said integrated information unit is provided on a same side of said metal layer as said working electrode and said reference electrode or on an opposite side of said metal layer.

10. The biosensor of claim 1, wherein said metal layer further has a counter electrode to facilitate a current flow to said working electrode.

11. The biosensor of claim 1, wherein said working electrode and said reference electrode can be made of a first metal material and said integrated information unit can be made of a second metal material, said first metal material may be the same as said second metal material or different from said second metal material.

12. The biosensor of claim 1, wherein said plurality of digital on and off points can be divided into a first group and a second group, and wherein any of said plurality of digital on and off points in said first group is assigned to generate signals corresponding to said electrical response, whereas any of said plurality of digital on and off points in said second group is assigned to generate signals corresponding to said coding information.

13. The biosensor of claim 12, wherein said plurality of digital on and off points in said first group is electrically coupled to said working electrode and said reference electrode.

14. The biosensor of claim 12, wherein said plurality of digital on and off points in said first group is electrically coupled to a counter electrode.

15. An electrochemical biosensor, comprising:

a substrate;

a non-metal layer disposed on said substrate, wherein a first end of said non-metal layer is formed with a reaction region by a working electrode and a reference electrode provided on said non-metal layer, said reaction region is applied with an enzyme so that an electrical response is generated when said enzyme and a test sample form a chemical reaction,

a conductive film layer having an integrated information unit provided thereon so as to provide both coding information about said biosensor and said electrical response,

wherein said integrated information unit is provided with a plurality of digital on and off points capable of generating signals corresponding to said coding information and said electrical response.

16. The biosensor of claim 15, wherein said integrated information unit is formed by cutting on said conductive film layer so as to create different resistances.

17. The biosensor of claim 16, wherein said cutting process can be a laser cutting process.

18. The biosensor of claim 15, wherein each of said plurality of digital on and off points can be enabled by providing an electrical connection therethrough.

19. The biosensor of claim 18, wherein said plurality of digital on and off points can be implemented through a general purpose input/output (GPIO) connection.

20. The biosensor of claim 15, wherein said coding information is calibration information.

21. The biosensor of claim 15, wherein said conductive film layer can be disposed on a same side of said substrate as said non-metal layer or an opposite side of said substrate.

22. The biosensor of claim 15, wherein said conductive film may be an Indium Tin Oxide (ITO) conductive film, an Indium Zin Oxide (IZO) conductive film, or any equivalent thereof.

23. The biosensor of claim 15, wherein said non-metal layer further has a counter electrode to facilitate a current flow to said working electrode.

24. The biosensor of claim 15, wherein said plurality of digital on and off points can be divided into a first group and a second group, and wherein any of said plurality of digital on and off points in said first group is assigned to generate signals corresponding to said electrical response, whereas any of said plurality of digital on and off points in said second group is assigned to generate signals corresponding to said coding information.

25. The biosensor of claim 24, wherein said plurality of digital on and off points in said first group is electrically coupled to said working electrode and said reference electrode.

26. The biosensor of claim 24, wherein said plurality of digital on and off points in said first group is electrically coupled to a counter electrode.

27. An electrochemical biosensor testing device for use with a biosensor provided with an integrated information unit containing both coding information about said biosensor, and an electrical response generated when an enzyme applied on a reaction region formed by a working electrode and a reference electrode provided on said biosensor forms a chemical reaction with a test sample, said testing device comprising:

a housing defining an slot for receiving said biosensor;

a single connector having a plurality of terminals for electrically coupling to said biosensor; and

a microcontroller electrically coupled to said single connector so as to calculate a test result,

wherein said single connector is capable of transmitting both said coding information and said electrical response to said microcontroller.

28. The device of claim 27, further comprising an ejection unit to facilitate an ejection of said biosensor.

29. The device of claim 28, wherein said ejection unit has a slidable button provided outside of said housing, said slidable button is connected to a first internal lever and a second internal lever interconnected to said single connector within said housing so that when a user slides said slidable button, said single connector moves along said slot to push said biosensor received in said slot out.

30. The device claim 28, further comprising a positioning unit, wherein said positioning unit has a plurality of flexible elements, and wherein said plurality of flexible elements are depressed as a user pushes said biosensor into said slot, and when said plurality of flexible elements are completely depressed, said user can push said biosensor no further.

31. The device of claim 30, wherein said positioning unit further comprises a first positioning element and a second positioning element so that when said user releases said biosensor, said first positioning element is connected to said second positioning element by a force exerted by said plurality of flexible elements so as to properly position said biosensor in said slot.

33. The device of claim 27, further comprising a speaker module electrically coupled to said microcontroller so as to output said test result.

34. The device of claim 27, further comprising a memory electrically coupled to said microcontroller such that said test result can be stored therein.

35. The device of claim 27, wherein said housing is in a pen-like shape.

32. The device of clam 28, wherein said ejection unit has a push button provided outside of said housing, and when a user pushes said push button, said push button allows said first positioning element and said second positioning element to disconnect from each other so that said biosensor is ejected out of said slot through a force exerted by said plurality of flexible elements.

36. An electrochemical biosensor testing device for use with a biosensor provided with an integrated information unit containing both coding information about said biosensor, and an electrical response generated when an enzyme applied on a reaction region formed by a working electrode and a reference electrode provided on said biosensor forms a chemical reaction with a test sample, said testing device comprising:

a housing defining an slot for receiving said biosensor;

a first connector and a second connector, each having a plurality of terminals for electrically coupling to said biosensor; and

a microcontroller electrically coupled to said first and said second connectors so as to calculate a test result,

wherein said first connector is capable of transmitting said coding information to said microcontroller, whereas said second connector is capable of transmitting said electrical response to said microcontroller.

37. The device of claim 36, further comprising an ejection unit to facilitate an ejection of said biosensor.

38. The device of claim 37, wherein said ejection unit has a slidable button provided outside of said housing, said slidable button is connected to a first internal lever and a second internal lever interconnected to said single connector within said housing so that when a user slides said slidable button, said single connector moves along said slot to push said biosensor received in said slot out.

39. The device claim 37, further comprising a positioning unit, wherein said positioning unit has a plurality of flexible elements, and wherein said plurality of flexible elements are depressed as a user pushes said biosensor into said slot, and when said plurality of flexible elements are completely depressed, said user can push said biosensor no further.

40. The device of claim 39, wherein said positioning unit further comprises a first positioning element and a second positioning element so that when said user releases said biosensor, said first positioning element is connected to said second positioning element by a force exerted by said plurality of flexible elements so as to properly position said biosensor in said slot.

42. The device of claim 36, further comprising a speaker module electrically coupled to said microcontroller so as to output said test result.

43. The device of claim 36, further comprising a memory electrically coupled to said microcontroller such that said test result can be stored therein.

44. The device of claim 37, wherein said housing is in a pen-like shape.

67. The device of claim 36, wherein said second connector is a SIM card connector.

41. The device of clam 37, wherein said ejection unit has a push button provided outside of said housing, and when a user pushes said push button, said push button allows said first positioning element and said second positioning element to disconnect from each other so that said biosensor is ejected out of said slot through a force exerted by said plurality of flexible elements.

45. An electrochemical biosensor testing system, comprising:

a biosensor provided with an integrated information unit containing both coding information about said biosensor, and an electrical response generated when an enzyme applied on a reaction region formed by a working electrode and a reference electrode provided on said biosensor forms a chemical reaction with a test sample; and

a biosensor testing device with a housing defining an slot for receiving said biosensor, said testing device having a single connector with a plurality of terminals for electrically coupling to said biosensor, and a microcontroller electrically coupled to said single connector so as to calculate a test result based on said coding information and said electrical response,

wherein said integrated information unit is provided with a plurality of digital on and off points to generate signals corresponding to said electrical response and said coding information.

46. The system of claim 45, wherein said plurality of digital on and off points is divided into a first group and a second group, and wherein said first group of said digital on and off points is electrically coupled to said working electrode and said reference electrode so as to generate signals corresponding to said electrical response, whereas said second group of said digital on and off points generates signals corresponding to said coding information.

47. The system of claim 45, wherein said biosensor has a substrate and a metal layer, and wherein a first end of said metal layer is provided with said reaction region, and a second end of said metal layer is provided with said integrated information unit by cutting on said second end of said metal layer so as to create different resistances.

48. The system of claim 47, wherein said cutting process can be a laser cutting process.

49. The system of claim 45, wherein any of said plurality of digital on and off points can be enabled by providing an electrical connection therethrough.

50. The system of claim 45, wherein said plurality of digital on and off points can be implemented through a general purpose input/output (GPIO) connection.

51. The system of claim 45, wherein said coding information is calibration information.

52. The system of claim 45, wherein said biosensor has a substrate and a non-metal layer, and wherein a first end of said non-metal layer is provided with said reaction region, and said integrated information unit is provided on a conductive film disposed on said non-metal layer covering at least a second end of said non-metal layer.

53. The system of claim 52, wherein said conductive film may be an Indium Tin Oxide (ITO) conductive film, an Indium Zin Oxide (IZO) conductive film, or any equivalent thereof.

54. The system of claim 47, wherein said integrated information unit is provided on a same side of said metal layer as said working electrode and said reference electrode or on an opposite side of said metal layer.

55. The system of claim 47, wherein said metal layer further has a counter electrode to facilitate a current flow to said working electrode.

56. The system of claim 45, wherein said working electrode and said reference electrode can be made of a first metal material and said integrated information unit can be made of a second metal material, said first metal material is the same as said second metal material, or said first metal material is different from said second metal material.

57. The system of claim 52, wherein said integrated information unit is provided on a same side of said substrate layer as said working electrode and said reference electrode or on an opposite side of said substrate.

58. The system of claim 46, wherein said first group of said plurality of digital on and off points is electrically coupled to a counter electrode.

59. The system of claim 45, wherein said biosensor testing device further comprises an ejection unit to facilitate an ejection of said biosensor.

60. The system of claim 59, wherein said ejection unit has a slidable button provided outside of said housing, said slidable button is connected to a first internal lever and a second internal lever interconnected to said single connector within said housing so that when a user slides said slidable button, said single connector moves along said slot to push said biosensor received in said slot out.

61. The system of claim 59, wherein said biosensor further comprises a positioning unit, wherein said positioning unit has a plurality of flexible elements, and wherein said plurality of flexible elements are depressed as a user pushes said biosensor into said slot, and when said plurality of flexible elements are completely depressed, said user can push said bio sensor no further.

62. The system of claim 61, wherein said positioning unit further comprises a first positioning element and a second positioning element so that when said user releases said biosensor, said first positioning element is connected to said second positioning element by a force exerted by said plurality of flexible elements so as to properly position said biosensor in said slot.

63. The system of claim 59, wherein said ejection unit has a push button provided outside of said housing, and when a user pushes said push button, said push button allows said first positioning element and said second positioning element to disconnect from each other so that said biosensor is ejected out of said slot through a force exerted by said plurality of flexible elements.

64. The system of claim 45, wherein said biosensor testing device further comprises a speaker module electrically coupled to said microcontroller so as to output said test result.

65. The system of claim 45, wherein said biosensor testing device further comprises a memory electrically coupled to said microcontroller such that said test result can be stored therein.

66. The system of claim 45, wherein said housing is in a pen-like shape.