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Lipid

  • US 20100297023A1
  • Filed: 12/21/2007
  • Published: 11/25/2010
  • Est. Priority Date: 12/22/2006
  • Status: Abandoned Application
First Claim
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1. A lipid of the formula (I)
R3R4N—

  • [Y]q

    (CpH2p)—

    X-Linker-NR1R2



    (I)whereinR3 and R4 are independently selected from H and hydrocarbyl groups;

    q is an integer selected from 1 to 10;

    Y represents a group (CnH2n)NR5, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R5 is independently selected from H and hydrocarbyl groups;

    p is an integer selected from 1 to 10;

    X is an optional group selected from —

    NR7

    , —

    C(═

    O)NR8

    , —

    NR9C(═

    O)—

    , —

    C(═

    O)—

    , —

    O—

    , and —

    NR10C(═

    O)O—

    , wherein each R7, R8, R9 and Ri0 is independently selected from H and hydrocarbyl groups,Linker is an optional group selected from amino acid residues, peptide residues and groups of the formulae —

    (OCH2CH2)1-10, —

    NR6(CvH2v)—

    C(═

    O), wherein R6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and —

    C(═

    O)(CH2)0-10

    CH2

    C(═

    O)—

    ;

    R1 is selected from acyclic groups having from 4 to 30 carbon atoms; and

    R2 is selected from H and acyclic groups having from 4 to 30 carbon atoms.

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