TARGETED INTERFERON DEMONSTRATES POTENT APOPTOTIC AND ANTI-TUMOR ACTIVITIES
First Claim
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1. A chimeric construct comprising an interferon attached to a targeting moiety that binds to tumor associated antigen, where said construct when contacted to a tumor cell results in the killing or inhibition of growth or proliferation of said tumor cell.
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Abstract
This invention provides novel chimeric moieties that show significant efficacy against cancers. In certain embodiments the chimeric moieties comprise a targeting moiety attached to an interferon. In certain embodiments, the chimeric moieties comprise fusion proteins where an antibody that specifically binds to a cancer marker is fused to interferon alpha (IFN-α).
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Citations
50 Claims
- 1. A chimeric construct comprising an interferon attached to a targeting moiety that binds to tumor associated antigen, where said construct when contacted to a tumor cell results in the killing or inhibition of growth or proliferation of said tumor cell.
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11. (canceled)
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31-33. -33. (canceled)
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36-37. -37. (canceled)
- 40. A nucleic acid that encodes a fusion protein, said fusion protein comprising an interferon attached to a C6 single-chain antibody or to an anti-CD20 single chain antibody.
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41-45. -45. (canceled)
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47-48. -48. (canceled)
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50. (canceled)
Specification