ELECTROLYTE MONITORING USING IMPLANTED CARDIAC RHYTHM MANAGEMENT DEVICE

• US 20100298670A1
• Filed: 05/20/2009
• Published: 11/25/2010
• Est. Priority Date: 05/20/2009
• Status: Abandoned Application

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Bharmi, Rupinder, Bornzin, Gene A.
• Application Number:
  US12/469,564
• Publication Number:
  US 20100298670A1
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/29 for permanent or long-term implantation
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators

Abstract

A method for diagnosing an electrolyte level with a cardiac rhythm management device includes recording intra-cardiac electrograms from multiple sites. The method determines the electrolyte level based upon a comparative analysis of intra-cardiac electrograms recorded from at least two of the sites. The electrolyte level can be quantified based upon a general model, or a patient specific model.

Claims

1. A method for diagnosing an electrolyte level with a cardiac rhythm management device, comprising:

recording intra-cardiac electrograms from a plurality of sites; and

determining the electrolyte level based upon a comparative analysis of the intra-cardiac electrograms from at least two of the sites.

2. The method of claim 1, in which the determining further comprises quantifying the electrolyte level using a model including at least one feature of the intra-cardiac electrograms from the at least two sites.

3. The method of claim 2, further comprising transmitting a warning when the diagnosed electrolyte level exceeds a threshold value.

4. The method of claim 2, further comprising deriving weighting factors of the model based upon data observed from a plurality of patients.

5. The method of claim 4, in which the deriving uses normalized features.

6. The method of claim 4, further comprising calibrating the model to a specific patient based upon a single measured electrolyte level for the specific patient and the corresponding intra-cardiac electrograms from the at least two sites of the specific patient.

7. The method of claim 6, in which the calibrating further comprises accounting for a plurality of electrolyte level measurements for the specific patient over time and the corresponding intra-cardiac electrograms from the at least two sites of the specific patient.

8. The method of claim 1, in which the determining the electrolyte level is further based upon a time comparative analysis of the intra-cardiac electrograms from the at least two sites.

9. The method of claim 1, in which the determining further comprises comparing repolarization features of the intra-cardiac electrograms from the at least two sites to determine a potassium level.

10. The method of claim 1, in which the determining further comprises comparing depolarization features of the intra-cardiac electrograms from the at least two sites to determine a sodium level.

11. The method of claim 1, in which the determining further comprises comparing plateau features of the intra-cardiac electrograms from the at least two sites to determine a calcium level.

12. The method of claim 1, further comprising wirelessly transmitting the determined electrolyte level to an external receiver.

13. A medical device for diagnosing an electrolyte level of a patient, comprising:

a first electrode adapted to be implanted at a first cardiac site to facilitate generating a first intra-cardiac electrogram;

a second electrode adapted to be implanted at a second cardiac site to facilitate generating a second intra-cardiac electrogram; and

a processing system that analyzes at least one feature from the first and second intra-cardiac electrograms to quantify the electrolyte level.

14. The medical device of claim 13, in which the device comprises a cardiac rhythm management device.

15. The medical device of claim 13, in which the device comprises an external monitor.

16. A system for diagnosing an electrolyte level of a patient, comprising:

means for recording intra-cardiac electrograms from a plurality of sites; and

means for quantifying the electrolyte level based upon a comparative analysis of the recorded intra-cardiac electrograms from at least two of the sites.

17. The system of claim 16, in which the quantifying means quantifies the electrolyte level based upon intra-cardiac electrograms from the plurality of sites measured at a plurality of times.

18. The system of claim 16, further comprising means for deriving weighting factors of an electrolyte calculating model based upon intra-cardiac electrogram data recorded from the at least two sites in each of a plurality of patients and corresponding measured electrolyte levels in the plurality of patients.

19. The system of claim 18, further comprising means for calibrating the model to a specific patient based upon a single measured electrolyte level for the specific patient and corresponding intra-cardiac electrograms from at least two sites of the specific patient.

20. The system of claim 19, in which the calibrating means further accounts, over time, for a plurality of electrolyte level measurements for the specific patient and the corresponding intra-cardiac electrograms from the at least two sites of the specific patient.