ANALYTE SENSOR

• US 20100298684A1
• Filed: 02/26/2010
• Published: 11/25/2010
• Est. Priority Date: 10/04/2006
• Status: Abandoned Application

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Leach, Jacob S., Wong, David K., Shults, Mark C., Brister, Mark, Petisce, James R., Woo, Kum Ming, Saint, Sean
• Application Number:
  US12/713,607
• Publication Number:
  US 20100298684A1
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host'"'"'s circulatory system.

Claims

1. A system for measuring an analyte, the system comprising:

a vascular access device configured to be in communication with a circulatory system of a host;

an analyte sensor configured to reside within the vascular access device, wherein the analyte sensor is configured to measure a concentration of an analyte within the circulatory system; and

a flow control device configured to draw blood into the vascular access device at a first flow rate of from about 0.001 ml/min to about 0.2 ml/min, wherein the flow control device is further configured to pass an infusion solution through the vascular access device at a second flow rate, wherein the first flow rate is not equal to the second flow rate.

2. The system of claim 1, wherein the analyte is glucose.

3. The system of claim 1, wherein the vascular access device comprises a catheter, and wherein the sensor is located within the catheter.

4. The system of claim 3, wherein the catheter is 21 gauge or smaller.

5. The system of claim 1, wherein the vascular access device comprises a catheter and a fluid coupler connectable to the catheter.

6. The system of claim 1, wherein the vascular access device comprises at least one of a venous catheter or an arterial catheter.

7. The system of claim 1, wherein the vascular access device comprises a Swann Gantz catheter.

8. The system of claim 1, wherein the vascular access device comprises a multi-lumen catheter, and wherein the sensor is located in one of the catheter'"'"'s lumens.

9. The system of claim 1, wherein the first flow rate is configured to substantially block mixing of the infusion solution and the sample.

10. The system of claim 1, wherein the second flow rate is from about 0.001 ml/min to about 2 ml/min.

11. The system of claim 10, wherein the second flow rate is from about 0.02 ml/min to about 0.35 ml/min.

12. The system of claim 10, wherein the second flow rate is configured to allow a temperature of the infusion solution to substantially equilibrate with a temperature of the host.

14. The system of claim 12, wherein the system is configured to push fluid through the vascular access device during movement of the valve from the first position to the second position.

15. The system of claim 12, wherein the valve is configured such that about 50 microliters or less of a fluid passes through the vascular access device during the movement of the valve between the first position and the second position.

13. A system for measuring an analyte, the system comprising:

a vascular access device configured to be in communication with a circulatory system of a host;

an analyte sensor configured to reside within the vascular access device, wherein the analyte sensor is configured to measure a concentration of an analyte within the circulatory system; and

a valve comprising a first position and a second position that is different from the first position, wherein the system is configured such that about 150 microliters or less of a fluid passes through the vascular access device during movement of the valve at a predetermined rate between the first position and the second position during a predetermined amount of time.