ADAPTIVE INSULIN DELIVERY SYSTEM
First Claim
1. A system for proactively monitoring glucose levels, the system comprising:
- a sensor that measures an indication of glucose and provides levels of glucose over a monitoring time period;
a memory having stored therein a safe range of glucose;
a device that provides a meal signal indicating that a meal has been consumed, the device also providing a medication administration signal indicating an amount of medication and a time that it was administered;
a processor configured to receive the meal signal, levels of glucose, and the safe range, wherein upon receiving the meal signal, the processor is further configured to;
monitor the levels of glucose beginning after the meal signal;
compare the levels of glucose to the safe range;
if a monitored glucose level is outside the safe range, determine a post-prandial vertex of the glucose level, andonce the vertex is determined, provide an action to return the glucose level to a target glucose level within the safe range, wherein the action includes consideration of a user parameter.
1 Assignment
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Accused Products
Abstract
A proactive system and method in which levels of glucose are monitored after a meal signal and compared to a safe range. If a monitored glucose level is outside the safe range, a post-prandial vertex of the glucose level is identified and an action is provided to more rapidly return the glucose level to a target level within the safe range than if no action was provided. In another aspect a control parameter in an IDM system is adjusted by determining a performance metric of the system as a function of the levels of glucose and a medication administration signal over a first window of time; and, if the performance metric is outside an expected range, adjusting the control parameter to adjust an amount of medication and to bring the performance metric inside the expected range.
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Citations
66 Claims
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1. A system for proactively monitoring glucose levels, the system comprising:
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a sensor that measures an indication of glucose and provides levels of glucose over a monitoring time period; a memory having stored therein a safe range of glucose; a device that provides a meal signal indicating that a meal has been consumed, the device also providing a medication administration signal indicating an amount of medication and a time that it was administered; a processor configured to receive the meal signal, levels of glucose, and the safe range, wherein upon receiving the meal signal, the processor is further configured to; monitor the levels of glucose beginning after the meal signal; compare the levels of glucose to the safe range; if a monitored glucose level is outside the safe range, determine a post-prandial vertex of the glucose level, and once the vertex is determined, provide an action to return the glucose level to a target glucose level within the safe range, wherein the action includes consideration of a user parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for proactively monitoring glucose levels, the method comprising:
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measuring an indication of glucose and providing levels of glucose over a monitoring time period; storing in a memory a safe range of glucose; providing a meal signal indicating that a meal has been consumed; providing a medication administration signal indicating an amount of medication and a time that it was administered; receiving the meal signal, levels of glucose, and the safe range, wherein upon receiving the meal signal; monitoring the levels of glucose beginning after the meal signal; comparing the levels of glucose to the safe range; if a monitored glucose level is outside the safe range, determining a post-prandial vertex of the glucose level, and once the vertex is determined, providing an action to return the glucose level to a target glucose level within the safe range, wherein the action includes consideration of a user parameter. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for integrated diabetes management, comprising:
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receiving at a controller a meal indication input; receiving at the controller and after the meal indication input a first set of sensed glucose readings in a user from a continuous glucose sensor; receiving at the controller a second set of sensed glucose readings in the user from the continuous glucose sensor, wherein the second set of sensed glucose readings begin later in time than the first set of sensed glucose readings and at least one of the second set of sensed readings is above a high glucose threshold; recording the first and second set of glucose readings on a memory medium; determining a first glucose level trend in the user as a function of the first set of glucose signals; determining a second glucose level trend in the user as a function of the second set of glucose signals; sending a signal indicative of a user glucose level peak from the controller to a display when the first glucose level trend and second glucose level trend diverge; and wherein the signal includes an amount of insulin required to reduce an insulin action time necessary to reduce a third set of sensed glucose readings below the high glucose threshold and to minimize a high glucose exposure. - View Dependent Claims (22, 23, 24)
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25. A method for adjusting a control parameter used in an integrated diabetes management (IDM) system, the method comprising:
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storing in a memory a control parameter; providing a medication administration signal representative of an amount of medication as a function of the control parameter; measuring levels of glucose over a monitoring time period; determining a performance metric as a function of the levels of glucose and the medication administration signal over a first window of time; and
,if the performance metric is outside an expected range, adjusting the control parameter to adjust the amount of medication and to bring the performance metric inside the expected range. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A system for adjusting a control parameter used in an integrated diabetes management (IDM) system, the system comprising:
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a memory having a control parameter stored thereon; a device configured to provide a medication administration signal representative of an amount of medication as a function of the control parameter, the device being further configured to measure levels of glucose over a monitoring time period; a processor configured to determine a performance metric as a function of the levels of glucose and the medication administration signal over a first window of time, such that, if the performance metric is outside an expected range, the processor is further configured to adjust the control parameter to adjust the medication administration signal and to bring the performance metric inside the expected range. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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59. A method for integrated diabetes management, comprising:
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providing a controller with a control parameter; sampling at the controller a first set of insulin delivery commands over a first window of time; sampling at the controller a second set of insulin delivery commands over a second window of time, wherein the first and second insulin delivery commands provide information to deliver an amount of insulin and are determined as a factor of a difference between a sensed glucose value and a target glucose value and a control parameter; determining a first performance metric as a function of the first set of insulin delivery commands; determining a second performance metric as a function of the second set of insulin delivery commands; adjusting the control parameter as a function of the first and second performance metric to generate an adjusted control parameter; determining a future insulin delivery command as a function of the adjusted control parameter; and graphically displaying information representative of the future insulin delivery command on a graphic display. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66)
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Specification