Rapid Shallow Breathing Detection for use in Congestive Heart Failure Status Determination

• US 20100298732A1
• Filed: 07/30/2010
• Published: 11/25/2010
• Est. Priority Date: 09/16/2005
• Status: Active Grant

• Current Assignee: John D. Hatlestad, Marina Brockway, Yi Zhang, Yousufali H. Dalal
• Original Assignee: John D. Hatlestad, Marina Brockway, Yi Zhang, Yousufali H. Dalal
• Inventors: Zhang, Yi, Hatlestad, John D., Dalal, Yousufali H., Brockway, Marina
• Granted Patent: US 7,993,280 B2
• Time in Patent Office: Days
• US Class Current: 600/529
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/091 Measuring volume of inspired or expired gases, e.g. to determine lung capacity
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient'"'"'s congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient'"'"'s measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.

Claims

1. A system, comprising:

a medical device comprising sensing circuitry;

detection circuitry disposed in the medical device and coupled to the sensing circuitry, the detection circuitry configured to detect one or more respiratory parameters;

a memory configured to store a baseline weight of a patient; and

a processor coupled to the memory and the detection circuitry, the processor configured to compute a change in the one or more respiratory parameters relative to a first threshold, compute a prediction of change in patient weight based on the computed change in the one or more respiratory parameters, and generate an output signal in response to the patient weight change prediction exceeding a second threshold.

2. The system of claim 1, wherein the processor is configured to update the first and second thresholds in response to the change in the one or more respiratory parameters exceeding the first threshold and the patient weight change prediction exceeding the second threshold.

3. The system of claim 1, wherein the change in the one or more respiratory parameters represents a cumulative change or slope of change in the one or more respiratory parameters.

4. The system of claim 1, wherein the processor is configured to compute the patient weight change prediction by deriving coefficients based on a relationship between predicted patient weight change relative to change in the one or more respiratory parameters.

5. The system of claim 4, wherein the processor is configured to derive the coefficients from a linear regression of the patient weight change prediction relative to the change in the one or more respiratory parameters.

6. The system of claim 1, wherein the processor is configured to generate a baseline relationship between the patient weight change prediction relative to change in respiration rate for the patient, and update the baseline relationship in response to a change in therapy delivered to the patient or a change in patient condition.

7. The system of claim 1, wherein the medical device is at least partially implantable in the patient, and the processor configured to generate the output signal comprises a processor of the at least partially implantable medical device.

8. The system of claim 1, wherein the medical device is configured for implantation in the patient, and the processor is disposed in the implantable medical device.

9. The system of claim 1, wherein the processor configured to generate the output signal comprises at least a processor of a patient-external system.

10. The system of claim 1, wherein at least the sensing circuitry comprises one or more implantable sensing components.

11. The system of claim 1, wherein the one or more respiratory parameters comprises respiration rate.

12. The system of claim 1, wherein the one or more respiratory parameters comprises an index indicative of rapid shallow breathing by the patient.

13. The system of claim 12, wherein the index is derived by computing a respiration rate and a tidal volume for each patient breath.

14. The system of claim 1, wherein the one or more respiratory parameters comprises an index indicative of dyspnea.

15. The system of claim 1, wherein the output signal comprises a signal for facilitating automated initiation, adjustment or termination of therapy delivery to the patient.

16. The system of claim 1, further comprising a user interface coupled to the processor and configured to receive the patient'"'"'s baseline weight for storage in the memory.

17. The system of claim 16, further comprising a weight scale configured to communicatively coupled to the user interface and configured to provide the patient'"'"'s weight.

18. The system of claim 1, wherein the processor is configured to generate an output signal indicative of the patient'"'"'s congestive heart failure status based on the change in the one or more respiratory parameters and the patient weight change prediction relative to the patient'"'"'s baseline weight.

19. A method, comprising:

detecting one or more respiratory parameters;

storing a baseline weight of a patient;

computing a change in the one or more respiration parameters relative to a first threshold;

computing a prediction of change in patient weight based on the change in the one or more respiratory parameters; and

generating an output signal in response to the patient weight change prediction exceeding a second threshold.

20. The method of claim 19, comprising updating the first and second thresholds in response to the change in the one or more respiratory parameters exceeding the first threshold and the patient weight change prediction exceeding the second threshold.

21. The method of claim 19, wherein computing the patient weight change prediction comprises deriving coefficients based on a relationship between patient weight change prediction relative to change in the one or more respiratory parameters.

22. The method of claim 21, wherein deriving the coefficients comprises deriving the coefficients from a linear regression of patient weight change prediction relative to change in the one or more respiratory parameters.

23. The method of claim 19, wherein at least detecting the one or more respiratory parameters comprises detecting the one or more respiratory parameters from within the patient'"'"'s body.

24. The method of claim 19, comprising generating an output signal indicative of the patient'"'"'s congestive heart failure status based on the change in the one or more respiratory parameters and the patient weight change prediction relative to the patient'"'"'s baseline weight.