DEVICES AND METHODS FOR IN-LINE SAMPLE PREPARATION OF MATERIALS
First Claim
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1. A microfluidic device for in-line sample preparation of one or more materials comprising:
- an in-line tangential flow component comprising;
a first channel through which a sample flows;
one or more additional channels;
wherein the first channel and the one or more additional channels are separated by a membrane comprising silicon, silicon nitride or combinations thereof; and
wherein a differential is present between the first channel and the additional channel that is separated by the membrane.
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Abstract
A microfluidic device for in-line sample preparation of one or more materials. The microfludic device comprises an in-line tangential flow component. The in-line tangential flow component comprises a first channel through which the sample flows; and one or more additional channels. The first channel and the one ore more channels are separated by a membrane; and wherein a differential is present between the first channel and additional channel that is separated by the membrane.
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20 Claims
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1. A microfluidic device for in-line sample preparation of one or more materials comprising:
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an in-line tangential flow component comprising; a first channel through which a sample flows; one or more additional channels; wherein the first channel and the one or more additional channels are separated by a membrane comprising silicon, silicon nitride or combinations thereof; and wherein a differential is present between the first channel and the additional channel that is separated by the membrane. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 19, 20)
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3. (canceled)
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12. A microfluidic device for in-line desalting one or more materials comprising:
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an in-line tangential flow component comprising; a first channel through which a sample flows; one or more additional channels; wherein the first channel and the one or more additional channels are separated by a membrane comprising silicon, silicon nitride or combinations thereof; and wherein an ionic differential is present between the first channel and additional channel that is separated by the membrane. - View Dependent Claims (13, 14, 15, 16)
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17. A microfluidic device for in-line concentration one or more materials comprising:
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an in-line tangential flow component comprising; a first channel through which a sample flows; one or more additional channels; wherein the first channel and the one or more additional channels are separated by a membrane comprising silicon, silicon nitride or combinations thereof; and wherein an electrical differential is present between the first channel and additional channel that is separated by the membrane.
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18. A method for in-line concentration of one or more materials comprising:
providing a microfluidic device comprising; an in-line tangential flow component comprising; a first channel through which a sample feed flows; one or more additional channels; wherein the first channel and the one or more additional channels are separated by a membrane; and
wherein a differential is present between the first channel and additional channel that is separated by the membrane;introducing the sample feed in the first channel and allowing the sample feed to flow in a tangential manner from the first channel to the one or more additional channels through the porous membrane based on the differential.
Specification