DRUG DELIVERY SYSTEMS USING FC FRAGMENTS
First Claim
Patent Images
1. A particle comprising an agent encapsulated in a particle, wherein the particle is associated with an FcRn binding partner.
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Accused Products
Abstract
The present invention provides drug delivery systems comprising FcRn binding partners (e.g., FcRn binding partner, Fc fragment) associated with a particle or an agent to be delivered. Inventive drug delivery systems allow for binding to the FcRn receptor and transcytosis into and/or through a cell or cell layer. Inventive systems are useful for delivering therapeutic agents across the endothelium of blood vessels or the epithelium of an organ.
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Citations
111 Claims
- 1. A particle comprising an agent encapsulated in a particle, wherein the particle is associated with an FcRn binding partner.
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47. A conjugate for drug delivery comprising a therapeutic, diagnostic, prognostic, or prophylactic an agent associated with an IgG Fc fragment FcRn binding partner, wherein the IgG Fc fragment comprises an amino acid sequence that is at least 80% identical to any of SEQ ID NOs.:
- 1-6 or comprises at least about 20 contiguous amino acids of any of SEQ ID NOs.;
1-6. - View Dependent Claims (66, 72, 73, 75, 76, 78, 86, 87, 88, 110, 111)
- 1-6 or comprises at least about 20 contiguous amino acids of any of SEQ ID NOs.;
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95. A pharmaceutical composition comprising an agent associated with an FcRn binding partner.
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Specification