PROBIOTIC COMPOSITION USEFUL FOR DIETARY AUGMENTATION AND/OR COMBATING DISEASE STATES AND ADVERSE PHYSIOLOGICAL CONDITIONS

• US 20100303782A1
• Filed: 07/20/2010
• Published: 12/02/2010
• Est. Priority Date: 08/29/2003
• Status: Active Grant

• Current Assignee: Cobb & Associates Inc.
• Original Assignee: Cobb & Associates Inc.
• Inventors: COBB, Mark L., Cobb, Alyson
• Granted Patent: US 8,192,733 B2
• Time in Patent Office: Days
• US Class Current: 424/93.462
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23P 10/30 Encapsulation of particles, e.g. foodstuff additives
• CPC Class Codes: A61K 31/702 Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
• CPC Class Codes: A61K 35/742 Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 27/14 Decongestants or antiallergics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: Y10S 435/822 using bacteria or actinomycetales

Abstract

A probiotic composition including the bacilli (1) Bacillus subtilis, (2) Bacillus coagulans, and (3) Enterococcus faecium. The composition may further include a carrier medium, such as fructo-oligo-saccharides (FOS), as incorporated in a dose form such as a pill, capsule, powder or sachet. The compositions of the disclosure may be usefully employed as health or nutritional supplements, food additives, or therapeutic agents for combating a wide variety of physiological disorders, such as irritable bowel syndrome, autism, and fibromyalgia.

Claims

1. A method of dietary augmentation, comprising administering to a human subject a probiotic composition dose form comprising a capsule containing a probiotic composition consisting of 100 million colony forming units (CFUs) of Bacillus subtillis, 200 million CFUs of Bacillus coagulans, 100 million CFUs of Enterococcus faecium, and a carrier medium consisting of fructo-oligosaccharides, according to a dosing schedule comprising a single capsule per day of the dose form for a first week, a single capsule twice daily of the dose form for a second and third week, and two capsules twice daily of the dose form thereafter.

2. The method of claim 1, wherein the human subject is afflicted with one or more of the conditions selected from the group consisting of deleterious fungal overgrowth, Candidiasis, autism (including autism per se as well as milder variants such as Aspergers syndrome), delayed development, acid reflux disease, vaginal yeast infections, impaired hearing, chronic ear infections, seasonal allergies, depression, Fibromyalgia syndrome, Crohn'"'"'s disease, colitis, irritable bowel syndrome, interstitial cystitis, acne, sinusitis, rheumatoid arthritis, chronic fatigue syndrome, asthma, attention deficit disorder, attention deficit/hyperactivity disorder, rosacea, multiple sclerosis, hyperglycemia, Mé

niè

re'"'"'s disease, Addison'"'"'s disease, Parkinson'"'"'s disease, Lou Gehrig'"'"'s disease, ankylosing spondylitis, celiac disease, Graves'"'"' disease, Guillain-Barre'"'"' syndrome, Hashimoto'"'"'s disease, lupus erythematosus, myasthenia gravis, Sjogren'"'"'s syndrome, alopecia universalis, endometriosis, eczema, seborrheic dermatitis, jock itch, hives, athlete'"'"'s foot, psoriasis, sarcoidosis, schizophrenia, scleroderma, ulcerative colitis and vulvodynia.

3. The method of claim 2, wherein the probiotic composition effects an amelioration of the afflicted condition(s).

4. The method of claim 3, wherein said amelioration comprises reduction of adverse symptoms of the afflicted condition(s).