N-HALAMINE FORMULATIONS WITH ENHANCED ANTIMICROBIAL ACTIVITY

• US 20100303930A1
• Filed: 05/28/2010
• Published: 12/02/2010
• Est. Priority Date: 05/29/2009
• Status: Abandoned Application

• Current Assignee: Alcon Research Limited (Nestle SA)
• Original Assignee: Alcon Research Limited (Nestle SA)
• Inventors: Carey, Thomas Christopher, Ketelson, Howard Allen, Schlitzer, Ronald L., Dassanayake, Nissanke L.
• Application Number:
  US12/789,965
• Publication Number:
  US 20100303930A1
• Time in Patent Office: Days
• US Class Current: 424/665
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 33/14 containing nitrogen-to-halogen bonds
• CPC Class Codes: A01N 43/40 six-membered rings
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds

Abstract

The present invention relates to antimicrobial formulations comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine. The present invention is further directed to formulations for disinfecting a contact lens comprising an N-halamine and a quantity of sodium chlorite sufficient to enhance the antimicrobial efficacy of the N-halamine.

Claims

1. A sterile, aqueous ophthalmic composition comprising an N-halamine of Formula (I):

2. A composition according to claim 1 wherein said N-halamine is 1-chloro-2,2,6,6-tetramethyl-4-piperidinol.

3. A composition according to claim 1 wherein said N-halamine is present at a concentration of from 0.0001 to 0.1 w/v % and said chlorite compound is present at a concentration of 0.001 to 0.01 w/v %.

4. A composition according to claim 3 wherein said N-halamine is present at a concentration of from 0.005 to 0.01 w/v % and said chlorite compound is present at a concentration of 0.001 to 0.01 w/v %.

5. A composition according to claim 1 wherein said N-halamine is 1-chloro-2,2,6,6-tetramethyl-4-piperidinol and said chlorite is sodium chlorite.

6. A composition according to claim 5 wherein said N-halamine is present at a concentration of 0.006 and said sodium chlorite is present at a concentration of 0.006.

7. A composition according to claim 1 wherein said N-halamine and said chlorite compound are present in a quantity sufficient to preserve said composition.

8. A method for disinfecting and/or cleaning a contact lens comprising:

contacting a contact lens with a composition according to claim 1.

9. A method according to claim 8 wherein said composition has a pH of 6.0 to 8.0

10. A method according to claim 9 wherein said composition has a pH of 6.5 to 7.8.

12. A method for disinfecting surfaces comprising:

contacting the surface to be disinfected with a composition according to claim 1.

11. A disinfecting tablet soluble in aqueous solution, said tablet comprising an N-halamine of Formula (I)