Nucleoside Prodrugs and Uses Thereof

• US 20100305060A1
• Filed: 11/26/2008
• Published: 12/02/2010
• Est. Priority Date: 11/29/2007
• Status: Abandoned Application

• Current Assignee: Metabasis Therapeutics, Inc. (Ligand Pharmaceuticals, Inc.)
• Original Assignee: Ligand Pharmaceuticals, Inc.
• Inventors: Reddy, K. Raja, Hecker, Scott J.
• Application Number:
  US12/745,419
• Publication Number:
  US 20100305060A1
• Time in Patent Office: Days
• US Class Current: 514/51
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/14 for RNA viruses
• CPC Class Codes: C07H 19/10 with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

This application provides compositions or compounds as disclosed herein that are suitable for treating hepatic viral diseases, such as hepatitis C(HCV).

Claims

1-10. -10. (canceled)

11. A compound of general formula III

12. The compound of claim 11,

wherein B is

13. The compound of claim 11, wherein V is selected from the group consisting of phenyl and pyridyl, each unsubstituted or substituted by one or two halogens or a pharmaceutically acceptable salt thereof.

14. The compound of claim 11, wherein V is selected from the group consisting of 3-chlorophenyl, 3,5-dichlorophenyl, 3,5-difluorophenyl, 3-pyridyl and 4-pyridyl or a pharmaceutically acceptable salt thereof.

18. The compound of claim 11, wherein V is 3-chlorophenyl or a pharmaceutically acceptable salt thereof.

16. The compound of claim 11, wherein V is 3-chlorophenyl,

and B

17. The compound of claim 11, wherein said compound has the formula:

19. The composition of claim 18, wherein said compound is

20. A method of treating hepatitis C infection or viral hepatitis comprising the administration of a compound or a pharmaceutically acceptable salt thereof according to claim 11 to an individual infected with hepatitis C or having viral hepatitis.

21. The method of claim 20, wherein said compound is

18-1. A composition comprising a compound according to claim 11 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, diluent, stabilizer or excipient.