Gentle-Acting Skin-Disinfectants and Hydroalcoholic Gel Formulations

• US 20100305211A1
• Filed: 08/10/2010
• Published: 12/02/2010
• Est. Priority Date: 10/23/2001
• Status: Active Grant

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta, Sampath, Lester, Gaonkar, Trupti A., Caraos, Lauser
• Granted Patent: US 8,293,802 B2
• Time in Patent Office: Days
• US Class Current: 514/635
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 31/79 Polymers of vinyl pyrrolidone
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/347 Phenols
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin. Hydroalcoholic gel composition containing alcohol, water, hydrogel, and emollient or emulsifier, wherein the composition has a viscosity of below 2000 centipoises at between 20 and 40° C. This skin-friendly hydroalcoholic gel composition, which can be further combined with silicone polymer, emollient solvent, thickening agent and antimicrobial agent, enhances rapid and long-term antimicrobial efficacy.

Claims

1. An antimicrobial composition comprising synergistic effective amounts of octoxyglycerin, a quaternary ammonium compound, and at least one antimicrobial agent selected from the group consisting of a biguanide compound, triclosan, phenoxyethanol, an iodine compound, parachlorometaxylenol and mixtures thereof.

2. The composition of claim 1 wherein the concentration of octoxyglycerin is between 1 and 5 percent (volume/volume).

3. The composition of claim 1 wherein the concentration of quaternary ammonium compound is between 0.01 and 0.3 percent.

4. The composition of claim 1, wherein the antimicrobial agent is a biguanide compound.

5. The composition of claim 4, wherein the biguanide compound is at a concentration of between 0.05 and 4 percent.

6. The composition of claim 4, wherein the biguanide compound is at a concentration of between 0.05 and 2 percent.

7. The composition of claim 4, wherein the biguanide compound is a chlorhexidine compound.

8. The composition of claim 7, wherein the chlorhexidine compound is at a concentration of between 0.05 and 4 percent.

9. The composition of claim 7, wherein the chlorhexidine compound is at a concentration of between 0.05 and 1 percent.

10. The composition of claim 1, wherein the antimicrobial agent is triclosan.

11. The composition of claim 10, wherein triclosan is at a concentration of between 0.1 and 2 percent.

12. The composition of claim 10, wherein triclosan is at a concentration of between 0.3 and 1 percent.

13. The composition of claim 1, wherein the antimicrobial agent is phenoxyethanol.

14. The composition of claim 13, wherein phenoxyethanol is at a concentration of between 0.3 and 2 percent.

15. The composition of claim 1, wherein the antimicrobial agent is parachlorometaxylenol.

16. The composition of claim 1, wherein the parachlorometaxylenol is at a concentration of between 0.3 and 2 percent.

17. The composition of claim 1, which further comprises between 20 and 85 percent (volume/volume) of ethanol.

18. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.05 and 0.2 percent of benzalkonium chloride, and between 0.05 and 4 percent of chlorhexidine digluconate.

19. The antimicrobial composition of claim 18, which further comprises between 20 and 85 percent (volume/volume) of ethanol.

20. An antimicrobial composition comprising synergistic effective amounts of between 1 and 5 percent (volume/volume) octoxyglycerin, between 0.05 and 4 percent of chlorhexidine digluconate, between 0.3 and 2 percent of phenoxyethanol, between 0.01 and 0.3 percent of a quaternary ammonium compound, and between 20 and 85 percent of at least one alcohol selected from the group consisting of ethanol, isopropyl alcohol, and mixtures thereof.