TISSUE CONFORMING MICRONEEDLE DEVICE FOR DRUG DELIVERY OR BIOLOGICAL FLUID COLLECTION
First Claim
1. A device for administration of a drug to a contoured or flexible tissue surface, the device comprising:
- a microneedle array which comprisesa plurality of microneedles, each microneedle having a base portion, a tip end portion distal to the base portion, and body portion between the base portion and the tip end portion, andan elastically stretchable substrate which comprises a plurality of apertures, each of which are defined by both (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element integral with and connecting at least two of the substrate elements; and
at least one drug storage element, which contains a drug formulation, disposed adjacent to the microneedle array.
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Accused Products
Abstract
Microneedle arrays are provided for use on a contoured or flexible tissue surface. In one embodiment, the microneedle array includes a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween; and a flexible substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element connecting at least two of the substrate elements. The spring element may include a curved element, such as a C-shaped, U-shaped, or S-shaped element. Apertures may be defined, for example, by two substrate elements, which connected to three or four spring elements. A skin patch is provided for therapeutic or diagnostic applications, which includes the microneedle array and an adhesive material.
81 Citations
29 Claims
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1. A device for administration of a drug to a contoured or flexible tissue surface, the device comprising:
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a microneedle array which comprises a plurality of microneedles, each microneedle having a base portion, a tip end portion distal to the base portion, and body portion between the base portion and the tip end portion, and an elastically stretchable substrate which comprises a plurality of apertures, each of which are defined by both (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element integral with and connecting at least two of the substrate elements; and at least one drug storage element, which contains a drug formulation, disposed adjacent to the microneedle array. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 26, 27)
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20. A device for transdermal sampling of a biological fluid, the device comprising:
comprising; a microneedle array which comprises a plurality of microneedles, each microneedle having a base portion, a tip end portion distal to the base portion, and body portion between the base portion and the tip end portion, and an elastically stretchable substrate which comprises a plurality of apertures, each of which are defined by both (i) a plurality of substrate elements which are integral with the base portions of the microneedles, and (ii) at least one spring element integral with and connecting at least two of the substrate elements; and at least one collection reservoir for retaining a biological fluid sample drawn through the microneedle array. - View Dependent Claims (21, 28, 29)
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22. A method for manufacturing a microneedle array comprising:
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(a) forming an elastically stretchable substrate which comprises a plurality of apertures, each of which are defined by (i) a plurality of substrate elements, and (ii) at least one spring element connecting at least two of the substrate elements; and (b) forming a plurality of microneedles, each having a base portion, a tip end portion distal to the base portion, and body portion therebetween, wherein the base portions of the microneedles are integral with the substrate elements. - View Dependent Claims (23, 24, 25)
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Specification