ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF
First Claim
1. An adhesive complex coacervate comprising at least one polycation, at least one polyanion, and at least one multivalent cation, wherein at least one polycation or polyanion is a synthetic compound, and the polycation and/or polyanion are crosslinked with one another upon crosslinking.
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Accused Products
Abstract
Described herein is the synthesis of adhesive complex coacervates. The adhesive complex coacervates are composed of a mixture of one or more polycations, one or more poly anions, and one of more multivalent cations. The polycations and polyanions in the adhesive complex coacervate are crosslinked with one another by covalent bonds upon curing. The adhesive complex coacervates have several desirable features when compared to conventional bioadhesives, which are effective in water-based applications. The adhesive complex coacervates described herein exhibit good interfacial tension in water when applied to a substrate (i.e., they spread over the interface rather than being beaded up). Additionally, the ability of the complex coacervate to crosslink intermolecularly increases the cohesive strength of the adhesive complex coacervate. The adhesive complex coacervates have numerous biological applications as bioadhesives and drug delivery devices. In particular, the adhesive complex coacervates described herein are particularly useful in underwater applications and situations where water is present such as, for example, physiological conditions.
52 Citations
56 Claims
- 1. An adhesive complex coacervate comprising at least one polycation, at least one polyanion, and at least one multivalent cation, wherein at least one polycation or polyanion is a synthetic compound, and the polycation and/or polyanion are crosslinked with one another upon crosslinking.
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26. An adhesive complex coacervate produced by the process comprising
(a) preparing a polyelectrolyte complex comprising admixing at least one polycation, at least one polyanion, and at least one multivalent cation, wherein at least one polycation or polyanion is a synthetic compound, and the polycation and/or polyanion comprises at least one group capable of crosslinking with each other; - and
(b) adjusting the pH of the polyelectrolyte complex, the concentration of the at least one divalent cation, or a combination thereof to produce the adhesive complex coacervate. - View Dependent Claims (27, 28, 29, 30, 31, 34, 38)
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32. A polyelectrolyte complex comprising at least one polycation, at least one polyanion, and at least one multivalent cation, wherein at least one polycation or polyanion is a synthetic compound, and the polycation and/or polyanion comprises at least one group capable of crosslinking with each other.
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33. A complex coacervate comprising at least one polycation, at least one polyanion, and at least one multivalent cation, wherein at least one polycation or polyanion is a synthetic compound, and the polycation and/or polyanion comprises at least one group capable of crosslinking with each other.
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35. A method for applying an adhesive complex coacervate to a substrate, the method comprising applying simultaneously to the substrate (1) a first solution comprising a polycation having a first pH and (2) a second solution comprising a polyanion having a second pH, wherein (i) when the first pH is less than 7, the second pH is greater than 7;
- (ii) when the first pH is greater than 7, the second pH is less than 7;
(iii) wherein at least one polycation or polyanion is a synthetic compound;
(iv) the polyanion comprises at least one group capable of crosslinking with the polycation;
(v) the first solution and/or the second solution comprises at least one multivalent cation; and
(vi) and the first solution and/or second solution comprises an oxidant, wherein upon mixing of the first solution and second solution the polyanion and polycation crosslink with one another to produce the adhesive complex coacervate.
- (ii) when the first pH is greater than 7, the second pH is less than 7;
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36. A method for applying an adhesive complex coacervate to a substrate, the method comprising (1) applying to the substrate a first solution comprising a polycation followed by (2) applying a second solution comprising a polyanion and an oxidant, wherein (i) at least one polycation or polyanion is a synthetic compound;
- (ii) the polyanion comprises at least one group capable of crosslinking with the polycation;
(iii) the first solution and/or the second solution comprises at least one multivalent cation; and
the pH of the second solution is greater than the pH of the first solution, wherein the polyanion and polycation crosslink with one another to produce the adhesive complex coacervate.
- (ii) the polyanion comprises at least one group capable of crosslinking with the polycation;
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37. A method for applying an adhesive to a substrate, the method comprising (1) applying to the substrate a first solution comprising a polyanion followed by (2) applying a second solution comprising a polycation and an oxidant, wherein (i) at least one polycation or polyanion is a synthetic compound;
- (ii) the polyanion comprises at least one group capable of crosslinking with the polycation;
(iii) the first solution and/or the second solution comprises at least one multivalent cation; and
the pH of the second solution is greater than the pH of the first solution, wherein the polyanion and polycation crosslink with one another to produce the adhesive complex coacervate.
- (ii) the polyanion comprises at least one group capable of crosslinking with the polycation;
- 55. A polymer comprising a (1) a polymeric backbone, (2) one or more phosphate groups linked to the backbone, and (3) one or more hydroxyl aromatic groups linked to the backbone capable of undergoing oxidation in the presence of an oxidant.
Specification