APPARATUS AND METHOD FOR ADMINISTERING A THERAPEUTIC AGENT INTO TISSUE

• US 20100307928A1
• Filed: 06/18/2010
• Published: 12/09/2010
• Est. Priority Date: 06/15/2004
• Status: Abandoned Application

• Current Assignee: Ceramatec, Inc. (Trelleborg AB)
• Original Assignee: Ceramatec, Inc. (Trelleborg AB)
• Inventors: Joshi, Ashok V., Murphy, Kieran P., Nachlas, Jesse, Steppan, James
• Application Number:
  US12/818,664
• Publication Number:
  US 20100307928A1
• Time in Patent Office: Days
• US Class Current: 205/465
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 2017/00261 Discectomy
• CPC Class Codes: A61M 2005/006 for gases, e.g. CO2
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 2202/0216 Ozone
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: C01B 13/02 Preparation of oxygen by liquefying F25J
• CPC Class Codes: C01B 13/10 Preparation of ozone
• CPC Class Codes: C25B 1/13 Ozone

Abstract

An apparatus for administering a therapeutic is provided. In various embodiments, the apparatus includes a syringe having a barrel and a plunger and having an ozone generator associated therewith. The generator is initiated and a therapeutic gas is accumulated within the barrel, at which point it can be delivered from the barrel into a target site via a needle, thereby delivering therapeutic effects to that target site.

Claims

1. A method of producing a gaseous therapeutic agent comprising:

placing an accumulator within a barrel of a syringe into an accumulation configuration;

generating said therapeutic agent;

filling said accumulator with said therapeutic agent; and

,

automatically changing said accumulator into a delivery configuration from said accumulation configuration when a desired level of said agent has been generated.

2. The method of claim 1, wherein said therapeutic agent comprises an oxygen-ozone mixture.

3. The method of claim 2, wherein generating said therapeutic agent comprises providing an ozone generator for generating the oxygen-ozone mixture and a power source electronically coupled to the ozone generator.

4. The method of claim 3, wherein the ozone generator is configured to communicate with the accumulator.

5. The method of claim 4, wherein generating said therapeutic agent comprises:

delivering an electrical signal from the power source to the accumulator; and

passing an oxygen containing gas through an electrical field such that the oxygen interacts with the electrical field to create the oxygen-ozone mixture.

6. The method of claim 5, wherein the ozone generator comprises a corona discharge device.

7. The method of claim 6, wherein the corona discharge device comprises a dielectric and an electrode.

8. The method of claim 5, wherein the frequency of said electrical signal is between about one tenth of a kilohertz and about one thousand kilohertz.

9. The method of claim 8, wherein the frequency of said electrical signal is between about twenty kilohertz and about sixty kilohertz.

10. The method of claim 5, wherein the voltage of said electrical signal is between about one kilovolt and twenty kilovolts.

11. The method of claim 10, wherein the voltage of said electrical signal is between about three kilovolts and about six kilovolts.

12. The method of claim 3, wherein the generator is configured to operate at a temperature ranging between about 15°

C. and about 30°

C.

13. The method of claim 12, wherein the generator is configured to operate at a temperature ranging between about 20°

C. and about 25°

C.

14. The method of claim 5, wherein delivering an electrical signal comprises providing an on-off switch in electrical communication with the ozone generator and the power source.

15. The method of claim 3, wherein generating said therapeutic agent comprises:

providing an ozonated gel; and

heating said ozonated gel to allow the desorption of the ozone-oxygen mixture from said ozonated gel.

16. The method of claim 15, wherein said ozonated gel is formed by sparging ozone through olive oil and then chilling the olive oil.

17. The method of claim 3, wherein generating said therapeutic agent comprises irradiating oxygen that may be contained within the accumulator.

18. The method of claim 17, wherein irradiating oxygen comprises providing an ultraviolet light source configured to shine ultraviolet light on the oxygen.

19. The method of claim 18, wherein a wavelength of light generated by the ultraviolet light source ranges between about 100 nm and about 700 nm.

20. The method of claim 19, wherein a wavelength of light generated by the ultraviolet light source ranges between about 140 nm and about 200 nm.

21. The method of claim 3, wherein generating said therapeutic agent comprises:

providing an electrochemical cell configured to communicate with an accumulator, said electrochemical cell comprising an anode and a cathode; and

creating an electrical current between the anode and the cathode such that water that may be in the electrochemical cell electrolyzes to produce ozone and oxygen at the anode.

22. The method of claim 3, wherein the generator is configured to create a ratio of micrograms of ozone to cubic centimeters of oxygen, wherein the ratio ranges from about five to about one-hundred.

23. The method of claim 22, wherein the generator is configured to create a ratio of micrograms of ozone to cubic centimeters of oxygen, wherein the ratio ranges from about twelve to about forty.

24. The method of claim 23, wherein the generator is configured to create a ratio of micrograms of ozone to cubic centimeters of oxygen of about twenty.

25. The method of claim 1, wherein said therapeutic agent is generated within the accumulator.