INHIBITORS OF NCCA-ATP CHANNELS FOR THERAPY
First Claim
1. A method of treating and/or preventing progressive hemorrhagic necrosis in an individual, comprising the step of providing to the individual an effective amount of an inhibitor of a NCCa-ATP channel.
4 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury, are also provided. The present invention also concerns treatment and/or prevention of intraventricular hemorrhage in infants, including premature infants utilizing one or more inhibitors of the channel is provided to the infant, for example to brain cells of the infant.
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Citations
52 Claims
- 1. A method of treating and/or preventing progressive hemorrhagic necrosis in an individual, comprising the step of providing to the individual an effective amount of an inhibitor of a NCCa-ATP channel.
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- 12. A kit for treating and/or preventing PHN, comprising an inhibitor of NCCa-ATP channel.
- 15. A method of treating intraventricular hemorrhage in the brain of an infant or preventing intraventricular hemorrhage in the brain of an infant at risk for developing intraventricular hemorrhage, comprising administering an effective amount of an inhibitor of NCCa-ATP channel to the infant following birth and/or the mother prior to birth.
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- 45. A kit for treating and/or preventing intraventricular hemorrhage, comprising an inhibitor of NCCa-ATP channel.
Specification