Optimized Proteins that Target Ep-CAM

• US 20100311954A1
• Filed: 03/15/2010
• Published: 12/09/2010
• Est. Priority Date: 03/01/2002
• Status: Abandoned Application

• Current Assignee: Xencor, Inc.
• Original Assignee: Xencor, Inc.
• Inventors: Chamberlain, Aaron K., Lazar, Gregory Alan, Desjarlais, John R.
• Application Number:
  US12/724,309
• Publication Number:
  US 20100311954A1
• Time in Patent Office: Days
• US Class Current: 530/387.3
• CPC Class Codes: C07K 16/30 from tumour cells
• CPC Class Codes: C07K 2317/24 containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
• CPC Class Codes: C07K 2317/41 Glycosylation, sialylation, or fucosylation
• CPC Class Codes: C07K 2317/72 Increased effector function due to an Fc-modification
• CPC Class Codes: C07K 2317/732 Antibody-dependent cellular cytotoxicity [ADCC]

Abstract

Humanized Ep-CAM-targeting antibodies and methods of making and using the same are provided.

Claims

1. A variant anti-Ep-CAM antibody comprising a variant human Fc domain, said variant human Fc domain comprising at least one modification that alters binding of said antibody to an Fc receptor compared to a parent human Fc domain.

2-31. -31. (canceled)