SYSTEMS AND METHODS FOR MONITORING BLOOD PARTITIONING AND ORGAN FUNCTION

• US 20100312128A1
• Filed: 12/29/2009
• Published: 12/09/2010
• Est. Priority Date: 06/09/2009
• Status: Abandoned Application

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Keel, Allen J., Wenzel, Brian Jeffrey, Hou, Wenbo, Karst, Edward, Farazi, Taraneh Ghaffari
• Application Number:
  US12/648,595
• Publication Number:
  US 20100312128A1
• Time in Patent Office: Days
• US Class Current: 600/506
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/0265 using electromagnetic means, e.g. electromagnetic flowmeter
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4472 Wireless probes
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

Methods and systems for monitoring an organ of interest within a patient use one or more sensors to obtain one or more signals indicative of one or more of blood being provided to the organ of interest, blood being received from the organ of interest, and blood present in the organ of interest. Changes in an amount of blood being provided to the organ of interest, an amount of blood being received from the organ of interest, and/or an amount of blood present in the organ of interest are monitored based on changes in the obtained signal(s). Such methods and systems can be used to detect dysfunction of the organ of interest or tumor growth in the organ of interest, but are not limited thereto.

Claims

1. A method for monitoring an organ of interest within a patient, the method comprising:

(a) using one or more sensors to obtain one or more signals indicative of one or more of blood being provided to the organ of interest, blood being received from the organ of interest, and blood present in the organ of interest; and

(b) monitoring changes in one or more of an amount of blood being provided to the organ of interest, an amount of blood being received from the organ of interest, and an amount of blood present in the organ of interest, based on changes in at least one of the one or more obtained signals.

2. The method of claim 1, wherein each of the one or more sensors comprises an impedance sensor, each impedance sensor including at least two electrodes, and each of the obtained signals comprises an impedance plethysmography signal.

3. The method of claim 1, wherein each of the one or more sensors comprises an optical sensor, each optical sensor including a light source and a light detector, and each of the obtained signals comprises a photoplethysmography signal.

4. The method of claim 1, wherein step (a) includes using said one or more sensors to obtain one or more plethysmography signals indicative of one or more of blood being provided to the organ of interest, blood being received from the organ of interest, and blood present in the organ of interest.

5. The method of claim 1, wherein step (b) includes:

(b.1) determining, from time to time, one or more metrics based on at least one of the one or more obtained signals, wherein the one or more metrics is/are indicative of one or more of blood being provided to the organ of interest, blood being received from the organ of interest, and blood present in the organ of interest; and

(b.2) monitoring changes one or more said determined metrics, over time, to thereby monitor changes in one or more of an amount of blood being provided to the organ of interest, an amount of blood being received from the organ of interest, and an amount of blood present in the organ of interest.

6. The method of claim 5, wherein step (b.2) includes monitoring whether one or more of the amount of blood being provided to the organ of interest, the amount of blood being received from the organ of interest, and the amount of blood present in the organ of interest is increasing, decreasing or staying relatively the same.

7. The method of claim 5, wherein step (b) includes (b.3) comparing a said metric to a corresponding baseline;

and further comprising;

(c) triggering an alert and/or therapy if the said metric falls below or rises above the corresponding baseline by at least a specified threshold.

8. The method of claim 5, wherein a said metric determined at step (b.1) is indicative of blood volume of blood vessels known to provide blood to the organ of interest.

9. The method of claim 5, wherein a said metric determine at step (b.1) is indicative of venous oxygen saturation or arterial oxygen saturation.

10. The method of claim 5, wherein:

the organ of interest is a kidney;

step (a) includes using at least one said sensor to obtain a signal indicative of renal blood flow being provided to the kidney; and

step (b) includes monitoring changes in the obtained signal indicative of renal blood flow being provided to the kidney, to thereby monitor changes in the amount of renal blood flow being provided to the kidney.

11. The method of claim 10, wherein step (a) includes using at least one said sensor to obtain a plethysmography signal indicative of changes in blood volume of blood vessels selected from the group consisting of:

glomerular capillaries;

renal arteries; and

renal veins.

12. The method of claim 11, wherein:

step (b) includes

(b.1) determining, from time to time, a metric based the obtained plethysmography signal indicative of renal blood flow being provided to the kidney; and

(b.2) comparing the determined metric to a baseline; and

further comprising

(c) detecting kidney disfunction if the metric falls below the baseline by at least a specified threshold.

13. The method of claim 5, wherein a said metric determined at (b.1) is determined based on at least one of:

a peak-to-peak amplitude of one or more of the obtained signals;

an area under the curve of one or more of the obtained signals;

a full width at have max of one or more of the obtained signals; and

a downward slope of after a peak amplitude of one or more of the obtained signals

14. The method of claim 1, wherein:

step (a) comprises obtaining one or more optical signals indicative of absorption and/or scattering of light at different wavelengths caused by the blood present in the organ of interest.

15. The method of claim 1, wherein at least one said sensor is implanted extravascularly within the patient at a location adjacent to the organ of interest or one or more blood vessels that provide blood to or receive blood from the organ of interest.

16. The method of claim 1, wherein at least one said sensor is a non-implanted sensor that is located against the patient'"'"'s skin at a location adjacent to one or more blood vessels that provide blood to or receive blood from the organ of interest.

17. The method of claim 1, further comprising:

(c) triggering an alert and/or therapy if a monitored change in the one or more of an amount of blood provided to the organ of interest, an amount of blood being received from the organ of interest, and an amount of blood present in the organ of interest is indicative of dysfunction of the organ of interest.

18. The method of claim 1, further comprising:

(c) monitoring for growth of a tumor in the organ of interest based on the monitored changes in one or more of an amount of blood provided to the organ of interest, an amount of blood being received from the organ of interest, and an amount of blood present in the organ of interest; and

(d) triggering an alert if the monitored changes are indicative of tumor growth in the organ of interest.

19. A system for monitoring an organ of interest within a patient, comprising:

one or more sensors configured to obtain one or more signals indicative of one or more of blood being provided to the organ of interest, blood being received from the organ of interest, and blood present in the organ of interest; and

a monitor configured to monitor changes in one or more of an amount of blood being provided to the organ of interest, an amount of blood being received from the organ of interest, and an amount of blood present in the organ of interest, based on changes in at least one of the one or more of the signals obtained by said one or more sensors.

20. The system of claim 19, wherein the monitor is configured to:

determine, from time to time, one or more metrics based on at least one of the one or more obtained signals, wherein the one or more metrics is/are indicative of one or more of blood being provided to the organ of interest, blood being received from the organ of interest, and blood present in the organ of interest; and

monitor changes in the one or more determined metrics, over time, to thereby monitor changes in one or more of an amount of blood provided to the organ of interest, an amount of blood being received from the organ of interest, and an amount of blood present in the organ of interest.

21. The system of claim 20, wherein the monitor is also configured to trigger an alert and/or therapy if a monitored change in one or more said metrics is indicative of dysfunction of the organ of interest.

22. The system of claim 19, wherein each of the one or more sensors comprises an impedance sensor, each impedance sensor including at least two electrodes.

23. The system of claim 19, wherein each of the one or more sensors comprises an optical sensor, each optical sensor including a light source and a light detector.

24. A method for monitoring for sepsis, the method comprising:

(a) using one or more sensors to obtain one or more signals indicative of one or more of blood being provided to a vital organ, blood being received from the vital organ, and blood present in the vital organ;

(b) using one or more further sensors to obtain one or more signals indicative of one or more of blood being provided to a non-vital organ, blood being received from the non-vital organ, and blood present in the non-vital organ;

(c) monitoring for sepsis based on a comparison between the one or more signals obtained at step (a) and the one or more signals obtained at step (b); and

(d) triggering an alert and/or therapy if sepsis is detected.

25. The method of claim 24, wherein step (c) comprises:

(c.1) determining one or more metrics of one or more signals indicative of one or more of blood being provided to the vital organ, blood being received from the vital organ, and blood present in the vital organ;

(c.2) determining one or more metrics of one or more signals indicative of one or more of blood being provided to the non-vital organ, blood being received from the non-vital organ, and blood present in the non-vital organ; and

(c.3) determining one or more metrics indicative of a difference between a said metric determined at (c.1) and a corresponding said metric determined at (c.2); and

(c.4) monitoring for sepsis based on at least one said metric indicative of the difference determined at (c.3).