LONG LIFE HIGH CAPACITY ELECTRODE, DEVICE, AND METHOD OF MANUFACTURE

• US 20100312168A1
• Filed: 06/08/2010
• Published: 12/09/2010
• Est. Priority Date: 06/09/2009
• Status: Abandoned Application

• Current Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Original Assignee: TTI Ellebeau, Inc. (Ease Asset Management Ltd.)
• Inventors: Ito, Masao, Yoshida, Yoshimasa
• Application Number:
  US12/796,057
• Publication Number:
  US 20100312168A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

Electrodes, particularly electrochemically active electrodes, may benefit from one or more pretreatment cycles in which the electrode is substantially oxidized, reduced or otherwise exhausted prior to use in an end use application, for example active agent delivery via iontophoresis. For instance, electrode lifetime may be advantageously increased, even when used to delivery relatively high currents or used at high current densities. Such may be necessary to delivery therapeutically effect dosage regimes, for instance of oxycodone. Use of a nonwoven fibrous substrate printed with a sacrificial ink may be advantageous relative to other substrates. Use of certain Ag/AgCl inks may be advantageous over other Ag/AgCl inks.

Claims

1. A method of manufacture, the method comprising:

prior to an end use application, introducing a first electrode and a second electrode to an electrolytic medium;

prior to the end use application, applying an electrical potential of a first polarity to the first electrode and an electrical potential of a second polarity to the second electrode for a first duration of time until at least one of the first and the second electrodes is substantially oxidized or reduced; and

incorporating the first and the second electrodes into a device for the end use application.

2. The method of claim 1, further comprising:

prior to the end use application and following the first duration of time, applying an electrical potential of the second polarity to the first electrode and an electrical potential of the first polarity to the second electrode for a second duration of time until at least one of the first and the second electrodes is substantially reduced or oxidized.

3. The method of claim 2, further comprising:

prior to the end use application and following the second duration of time and preceding the incorporating of the first and second electrodes into the device for the end use application, applying an electrical potential of the first polarity to the first electrode and an electrical potential of the second polarity to the second electrode for a third duration of time until at least one of the first and the second electrodes is substantially oxidized or reduced.

4. The method of claim 1 wherein introducing a first electrode and a second electrode to an electrolytic medium includes placing the first and the second electrodes in a liquid electrolytic medium.

5. The method of claim 1 wherein introducing a first electrode and a second electrode to an electrolytic medium includes moving a first continuous web of electrode material and a second continuous web of electrode material through the electrolytic medium.

6. The method of claim 1 wherein the end use application is delivery of an active agent to a biological subject and wherein incorporating the first and the second electrodes into a device for the end use application includes locating one of the first or the second electrodes in an active electrode assembly of the device positioned to selectively apply an electrical potential to an active agent reservoir of the active electrode assembly and locating the other one of the first or the second electrodes in a counter electrode assembly of the device.

7. The method of claim 6, further comprising:

positioning a piece of nonwoven cloth proximate the first electrode; and

loading the piece of nonwoven cloth with an ionic active agent to be delivered in response to an electrical potential applied to the ionic active agent via the first electrode.

8. The method of claim 1 wherein the first and the second electrodes are each part of a respective substrate of material, and further comprising:

prior to the end use application and preceding the incorporating of the first and the second electrodes into the device for the end use application, separating the first and the second electrodes from the respective substrates of material.

9. The method of claim 1, further comprising:

prior to the end use application and preceding the introducing of the first and the second electrodes to the electrolytic medium, providing a substrate of nonwoven fibrous material, and

depositing a metal/metal salt on the substrate of nonwoven fibrous material to form the first electrode.

10. The method of claim 1, further comprising:

prior to the end use application and preceding the introducing of the first and the second electrodes to the electrolytic medium, plating a metal/metal salt on a substrate of absorbent nonwoven fibrous material to form the first electrode.

11. The method of claim 1, further comprising:

prior to the end use application and preceding the introducing of the first and the second electrodes to the electrolytic medium, printing a silver/silver chloride ink on a substrate of absorbent nonwoven fibrous material to form the first electrode.

12. The method of claim 1 wherein incorporating the first and the second electrodes into a device for the end use application occurs after introducing the first and the second electrodes to the electrolytic medium and after applying the electrical potential of the first polarity to the first electrode and the electrical potential of the second polarity to the second electrode for the first duration of time.

13. The method of claim 1 wherein applying an electrical potential of a first polarity to the first electrode and an electrical potential of a second polarity to the second electrode for a first duration of time until at least one of the first and the second electrodes is substantially oxidized or reduced includes applying the electrical potential of the first polarity to the first electrode until a capacity for oxidation or reduction of the first electrode is reduced by at least 50 percent relative to an oxidation or reduction capacity the first electrode before the first duration of time.

14. The method of claim 1 wherein applying an electrical potential of a first polarity to the first electrode and an electrical potential of a second polarity to the second electrode for a first duration of time until at least one of the first and the second electrodes is substantially oxidized or reduced occurs before physically associating any one of the first and the second electrodes with an active agent reservoir.

15. The method of claim 1 wherein applying an electrical potential of a first polarity to the first electrode and an electrical potential of a second polarity to the second electrode for a first duration of time until at least one of the first and the second electrodes is substantially oxidized or reduced occurs before loading an active agent in an active agent reservoir.

16. A device for an end use application, comprising:

a first electrode which has had an electrical potential of a first polarity applied for a duration of time until the first electrode has been substantially oxidized or reduced at least one before the end use application;

a second electrode which has had an electrical potential of a second polarity applied for a duration of time until the second electrode has been substantially oxidized or reduced at least once before the end use application; and

a circuit operable to apply a voltage across the first and the second electrodes during the end use application.

17. The device of claim 16 wherein the first electrode has an electrical potential of the second polarity applied for a duration of time until the first electrode has been substantially reconstituted prior to the end use.

18. The device of claim 16 wherein the first electrode has an electrical potential of the second polarity applied for a duration of time until the first electrode has been substantially reduced for a second time prior to the end use.

19. The device of claim 16, further comprising:

an active agent reservoir positioned on a delivery side of the first electrode.

20. The device of claim 19, further comprising:

an ionic active agent loaded in the active agent reservoir and selective transportable from the active agent reservoir in response to an electrical potential applied by the first electrode.

21. The device of claim 16, further comprising:

an absorbent nonwoven cloth active agent reservoir positioned overlaying a biological subject contacting side of the first electrode.

22. The device of claim 21, further comprising:

an absorbent nonwoven cloth electrolyte reservoir positioned overlying a biological subject contacting side of the second electrode; and

a backing structure that supports the first electrode, the second electrode, the circuit, the absorbent nonwoven cloth active agent reservoir and the absorbent nonwoven cloth electrolyte reservoir.

23. The device of claim 21 wherein the first electrode has an area of at least 40 cm² and is capable of delivering 12 mA for 24 hours when driven by the power source.

24. The device of claim 23 wherein the first electrode comprises a nonwoven cloth and a metal/metal salt material.

25. The device of claim 24 wherein the metal/metal salt material comprises an Ag/AgCl mixture of at least 50 mg/cm³.

26. The device of claim 24 wherein the first electrode comprises at least one of a metal foil or screen and has a thickness of at least 30 μ

m.

27. A device for an end use application of drug delivery, the device comprising:

a first sacrificial electrode;

a second electrode;

an drug reservoir positioned on a delivery side of the first electrode to be responsive to an electrical potential applied by the first sacrificial electrode to delivery a drug from the drug reservoir to a biological interface; and

a circuit operable to apply a voltage from a power source across the first and the second electrodes during the end use application, wherein the first sacrificial electrode has a capacity of delivering 0.3 mA/cm² for a 24 hour duration when driven by the circuit.

28. The device of claim 27 wherein the first sacrificial electrode is sized to delivery 12 mA for 24 hours when driven by the power source.

29. The device of claim 27 wherein the first sacrificial electrode has an area of at least 40 cm².

30. The device of claim 27 wherein the first sacrificial electrode comprises Ag/AgCl.

31. The device of claim 27 wherein the first sacrificial electrode comprises a piece of nonwoven cloth bearing an Ag/AgCl mixture.

32. The device of claim 27 wherein the first sacrificial electrode comprises a piece of polymer substrate bearing an Ag/AgCl mixture.

33. The device of claim 27 wherein the first sacrificial electrode comprises a piece of nonwoven cloth bearing an Ag/AgCl mixture of at least 50 mg/cm³.

34. The device of claim 27 wherein the first sacrificial electrode comprises a piece of foil having a thickness of at least 20 μ

m and the first sacrificial electrode has had an electrical potential of a first polarity applied for a first duration of time and an electrical potential of a second polarity applied for a second duration of time until the first electrode has been substantially oxidized at least once and reduced at least once before the end use application.

35. The device of claim 27 wherein the first sacrificial electrode comprises a piece of foil having a thickness of at least 30 μ

m and the first sacrificial electrode has had an electrical potential of a first polarity applied for a first duration of time and an electrical potential of a second polarity applied for a second duration of time until the first electrode has been substantially oxidized at least once and reduced at least once before the end use application.

36. The device of claim 27 wherein the first sacrificial electrode comprises a piece of foil having a thickness of at least 50 μ

m.

37. The device of claim 27 wherein the Ag/AgCl mixture has had an electrical potential of a first polarity applied for a first duration of time until the first electrode has been substantially oxidized at least one and has had an electrical potential of a second polarity, opposite the first polarity, applied for a second duration of time until reduced at least once before the end use application.

38. The device of claim 27, further comprising:

a therapeutically effective quantity of oxycodone stored in the drug reservoir.