Conditionally Replicating Viruses for Cancer Therapy
First Claim
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1. A viral vector comprising a nucleic acid encoding a viral DNA polymerase, wherein the encoded viral DNA polymerase comprises at least one amino acid mutation.
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Abstract
Described herein are viral vectors comprising a nucleic acid encoding a viral DNA polymerase wherein the encoded viral DNA polymerase comprises at least one amino acid modification. Also provided are methods of making and using the viral vectors.
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25 Claims
- 1. A viral vector comprising a nucleic acid encoding a viral DNA polymerase, wherein the encoded viral DNA polymerase comprises at least one amino acid mutation.
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