METHODS FOR TREATMENT AND DIAGNOSIS OF PSYCHIATRIC DISORDERS
First Claim
1. A method for treating a psychiatric disorder in a mammalian subject comprising administering to the subject a modulator of ErbB receptor signaling pathway in an amount effective to reduce or eliminate the psychiatric disorder in the subject or to prevent its occurrence or recurrence.
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Abstract
A method for preventing or treating a psychiatric disorder in a mammalian subject is provided. A method for preventing or treating a psychiatric disorder in a mammalian subject is provided which comprises administering to the subject a modulator of ErbB receptor signaling in an amount effective to reduce or eliminate the psychiatric disorder in the subject or to prevent its occurrence or recurrence. A method for diagnosis of a psychiatric disorder in a mammalian subject is provided.
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Citations
51 Claims
- 1. A method for treating a psychiatric disorder in a mammalian subject comprising administering to the subject a modulator of ErbB receptor signaling pathway in an amount effective to reduce or eliminate the psychiatric disorder in the subject or to prevent its occurrence or recurrence.
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26. A method for identifying a modulator of signaling in cells via an ErbB receptor signaling pathway comprising,
contacting a test compound with a cell-based assay system comprising a cell expressing ErbB receptor capable of signaling responsiveness to a ligand and expressing dopamine receptor capable of signaling responsiveness to dopamine, providing the ligand to the assay system in an amount selected to be effective to modulate ErbB receptor signaling, and detecting an effect of the test compound on ErbB receptor signaling in the assay system, effectiveness of the test compound in the assay being indicative of the modulation.
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36. A method for identifying a modulator of signaling in cells via an ErbB receptor signaling pathway comprising,
contacting a test compound with a tissue-based assay system comprising a tissue expressing ErbB receptor capable of signaling responsiveness to a ligand, providing the ligand to the assay system in an amount selected to be effective to modulate ErbB receptor signaling, and detecting an effect of the test compound on ErbB receptor signaling in the assay system by measuring a change in amplitude or frequency of gamma oscillatory activity, effectiveness of the test compound in the assay being indicative of the modulation.
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39. A method for screening a compound to treat a psychiatric disorder in a mammalian subject comprising,
contacting a test compound with a cell-based assay system comprising a cell expressing ErbB receptor capable of signaling responsiveness to a ligand and expressing D2 type receptor capable of signaling responsiveness to dopamine, providing the ligand to the assay system in an amount selected to be effective to modulate ErbB receptor signaling, and detecting an effect of the test compound on ErbB receptor signaling in the assay system, effectiveness of the test compound in the assay being indicative of efficacy of treatment in the mammalian subject.
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41. A method for diagnosing a psychiatric disorder in a mammalian subject comprising
isolating lymphocytes expressing NRG gene and ErbB receptor gene, analyzing splice variants of NRG mRNA or ErbB mRNA, and determining a predisposition to a psychiatric disorder on the basis of splice variants of NRG mRNA or ErbB mRNA.
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46. A method for diagnosing a psychiatric disorder in a mammalian subject comprising
isolating neural cells expressing NRG gene and ErbB receptor gene, analyzing polymorphisms of the NRG gene or the ErbB receptor gene, and determining a predisposition to a psychiatric disorder on the basis of polymorphisms of the NRG-1 gene or the ErbB4 receptor gene.
Specification