Compositions and Methods for Inhibiting Viral Replication
First Claim
1. A double-stranded ribonucleic acid (dsRNA) for inhibiting the replication of a (+) strand RNA virus, wherein the dsRNA comprises a sense RNA strand consisting of a nucleotide sequence which is substantially identical to at least a part of a 3′
- -untranslated region (3′
-UTR) of the (+) strand RNA virus and an antisense RNA strand which is complementary to at least a part of the sense RNA strand, and wherein each strand of the dsRNA is 21 to 24 nucleotides in length.
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Abstract
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3′-untranslated region (3′-UTR) of a (+) strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA, together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the (+) strand RNA virus, as well as methods for inhibiting viral replication.
13 Citations
28 Claims
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1. A double-stranded ribonucleic acid (dsRNA) for inhibiting the replication of a (+) strand RNA virus, wherein the dsRNA comprises a sense RNA strand consisting of a nucleotide sequence which is substantially identical to at least a part of a 3′
- -untranslated region (3′
-UTR) of the (+) strand RNA virus and an antisense RNA strand which is complementary to at least a part of the sense RNA strand, and wherein each strand of the dsRNA is 21 to 24 nucleotides in length. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10)
- -untranslated region (3′
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2-3. -3. (canceled)
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11. A pharmaceutical composition for inhibiting the replication of a (+) strand RNA virus in an mammal, comprising a dsRNA and a pharmaceutically acceptable carrier, wherein the dsRNA comprises a sense RNA strand consisting of a nucleotide sequence which is substantially identical to at least a part of a 3′
- -untranslated region (3′
-UTR) of the (+) strand RNA virus and an antisense RNA strand which is complementary to at least a part of the sense RNA strand, and wherein each strand of the dsRNA is 21 to 24 nucleotides in length. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
- -untranslated region (3′
-
12-13. -13. (canceled)
Specification