METHOD AND DEVICE FOR FILTERING PLATELETS
First Claim
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1. A method for removing antiplatelet agents and anticoagulants from a platelet preparation, comprising:
- flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration.
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Abstract
The present invention relates to methods for removing antiplatelet agents and anticoagulants from a platelet preparation. In one embodiment, the method includes the step of flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. In another embodiment, the method includes the step of passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants.
17 Citations
28 Claims
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1. A method for removing antiplatelet agents and anticoagulants from a platelet preparation, comprising:
flowing the platelet preparation through a filtering tube comprising a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for removing antiplatelet agents and anticoagulants from a platelet preparation, comprising:
passing the platelet preparation through porous material that specifically binds to the antiplatelet agents and anticoagulants. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for antiplatelet agents and anticoagulants from a platelet preparation using diafiltration, comprising:
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circulating the platelet preparation through a hollow fiber membrane capable of separating the antiplatelet agents and anticoagulants from the platelet preparation, wherein a diafiltration buffer is added to the platelet preparation during circulation to maintain a constant volume of the platelet preparation. - View Dependent Claims (22, 23, 24)
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25. A method for removing antiplatelet agents and anticoagulants from a platelet preparation, comprising:
flowing the platelet preparation through the surface of a filtering membrane and separating the antiplatelet agents and anticoagulants from the platelet preparation by tangential flow filtration. - View Dependent Claims (26)
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27. A filter for removing antiplatelet agents and anticiagulants from a platelet preparation, comprising:
- a nanofiber modified to bind specifically to an antiplatelet agent or an anticoagulant.
- View Dependent Claims (28)
Specification