CELL-MEDIATED DELIVERY AND TARGETED EROSION OF NONCOVALENTLY CROSSLINKED HYDROGELS
First Claim
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1. A method for targeted delivery of a therapeutic compound to a cell, the method comprising administering a hydrogel comprising a heparin-binding therapeutic compound to a cell, wherein the cell is capable of non-covalently binding the therapeutic compound;
- wherein the hydrogel comprises a cross-linked matrix comprising at least two polymer-LMWH conjugates, and at least one heparin-binding compound, wherein the polymer comprises PEG, wherein each polymer-LMWH conjugate comprises at least one polymer covalently bonded to at least one LMWH molecule, wherein a fraction of the polymer-LMWH conjugates is noncovalently bound with the heparin-binding compound, and wherein the heparin-binding compound comprises the therapeutic compound.
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Abstract
A method for targeted delivery of therapeutic compounds from hydrogels is presented. The method involves administering to a cell a hydrogel in which a therapeutic compound is noncovalently bound to heparin.
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11 Claims
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1. A method for targeted delivery of a therapeutic compound to a cell, the method comprising administering a hydrogel comprising a heparin-binding therapeutic compound to a cell, wherein the cell is capable of non-covalently binding the therapeutic compound;
- wherein the hydrogel comprises a cross-linked matrix comprising at least two polymer-LMWH conjugates, and at least one heparin-binding compound, wherein the polymer comprises PEG, wherein each polymer-LMWH conjugate comprises at least one polymer covalently bonded to at least one LMWH molecule, wherein a fraction of the polymer-LMWH conjugates is noncovalently bound with the heparin-binding compound, and wherein the heparin-binding compound comprises the therapeutic compound.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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