MODULATION OF HIF1 BETA EXPRESSION
First Claim
1. An antisense oligonucleotide 13 to 50 nucleobases in length which is specifically hybridizable with a nucleic acid molecule encoding human HIF1-beta, said antisense oligonucleotide comprising at least one modification selected from the group consisting of a modified internucleoside linkage, a modified sugar moiety and a modified nucleobase, wherein said antisense oligonucleotide inhibits expression of human HIF1-beta.
0 Assignments
0 Petitions
Accused Products
Abstract
Compounds, compositions and methods are provided for modulating the expression of HIF1-beta. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1-beta. Methods of using these compounds for modulation of HIF1-beta expression and for diagnosis and treatment of diseases and conditions associated with expression of HIF1-beta are provided.
22 Citations
20 Claims
- 1. An antisense oligonucleotide 13 to 50 nucleobases in length which is specifically hybridizable with a nucleic acid molecule encoding human HIF1-beta, said antisense oligonucleotide comprising at least one modification selected from the group consisting of a modified internucleoside linkage, a modified sugar moiety and a modified nucleobase, wherein said antisense oligonucleotide inhibits expression of human HIF1-beta.
Specification