Acoustic-Feedback Power Control During Focused Ultrasound Delivery

• US 20100318002A1
• Filed: 06/10/2010
• Published: 12/16/2010
• Est. Priority Date: 06/10/2009
• Status: Abandoned Application

• Current Assignee: InSightec Ltd.
• Original Assignee: InSightec Ltd.
• Inventors: Vitek, Shuki, Schmidt, Rita, Zadicario, Eyal, Prus, Oleg
• Application Number:
  US12/813,016
• Publication Number:
  US 20100318002A1
• Time in Patent Office: Days
• US Class Current: 601/2
• CPC Class Codes: A61B 17/22004 using mechanical vibrations, e.g. ultrasonic shock waves A61B17/225 takes precedence
• CPC Class Codes: A61B 17/22029 Means for measuring shock waves
• CPC Class Codes: A61B 2017/00106 ultrasonic
• CPC Class Codes: A61B 2017/22007 Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
• CPC Class Codes: A61B 2017/22028 arrays, e.g. phased arrays
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61N 2007/0039 using microbubbles
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Ultrasound energy is delivered to a patient in a controlled manner using a focused ultrasound system, thus maintaining the desired therapeutic effect without causing unwanted damage to surrounding tissue. An ultrasound transducer device includes multiple transducer elements, each of which is controlled by drive circuitry and a drive signal controller. An acoustic detector detects signals indicative of cavitation in tissue targeted by the transducer elements, and the drive signal controller manages the delivery of acoustic energy from the transducer elements based on the detected cavitation signals such that a therapeutic effect at the target tissue remains within an efficacy range.

Claims

1. A focused ultrasound system, comprising:

an ultrasound transducer device having a plurality of transducer elements;

an acoustic detector configured to detect signals indicative of cavitation in tissue targeted by the transducer elements;

drive circuitry coupled to the transducer elements; and

a drive signal controller coupled to the drive circuitry, the drive signal controller controlling delivery of acoustic energy from the transducer elements based at least in part on the detected cavitation signals so that a therapeutic effect at the target tissue remains within an efficacy range defined by an efficacy threshold and a safety ceiling.

2. The system of claim 1 wherein the acoustic detector comprises one or more hydrophones.

3. The system of claim 1 wherein the acoustic detector produces a cavitation signature.

4. The system of claim 3 wherein the cavitation signature comprises one or more control parameters correlated with the therapeutic effect.

5. The system of claim 4 wherein the acoustic detector assesses whether the therapeutic effect is within the efficacy range based on the at least one control parameter and the correlation.

6. The system of claim 4 wherein the efficacy range changes as the acoustic energy is delivered.

7. The system of claim 4 wherein the plurality of transducers operate at about 220 kHz and the control parameters comprise a measurement of an acoustic signal between about 50 kHz and about 120 KHz.

8. The system of claim 4 wherein the control parameters comprise a broadband median representing the median amplitude of the cavitation signal over a sensed acoustic frequency band.

9. The system of claim 5 wherein the drive signal controller increases sonication power of the ultrasound transducer if one or more of the control parameters indicate that the therapeutic effect is below the efficacy threshold.

10. The system of claim 5 wherein the drive signal controller decreases sonication power of the ultrasound transducer if one or more of the control parameters indicate that the therapeutic effect is above the safety ceiling.

11. A method for controlling ultrasound energy being delivered to a patient using a focused ultrasound system that comprises a transducer having a plurality of transducer elements, the method comprising:

delivering, via the transducer, ultrasound energy to a target tissue within the patient;

detecting signals indicative of cavitation in the target tissue;

controlling delivery of acoustic energy from the transducer elements based at least in part on the detected cavitation signals so that a therapeutic effect at the target tissue remains within an efficacy range defined by an efficacy threshold and a safety ceiling.

12. The method of claim 11 further comprising detecting the signals according to a prescribed periodicity.

13. The method of claim 11 wherein the signals are acoustic signals.

14. The method of claim 11 further comprising producing a cavitation signature based on the detected cavitation signals, the cavitation signature comprising one or more control parameters correlated with the therapeutic effect.

15. The method of claim 14 wherein the one or more control parameters comprises a broadband median representing the median amplitude of the cavitation signal over a sensed acoustic frequency band.

16. The method of claim 15 further comprising assessing whether the therapeutic effect is within the efficacy range based at least in part on the broadband median.

17. The method of claim 16 further comprising increasing power to the ultrasound transducer if one or more of the control parameters indicate that the therapeutic effect is below the efficacy threshold.

18. The method of claim 16 further comprising decreasing power to the ultrasound transducer if one or more of the control parameters are above the safety ceiling.

19. The method of claim 11 wherein the plurality of transducer elements operate at about 220 kHz and the control parameters comprise a measurement of a signal between about 50 kHz and about 120 KHz.

20. The method of claim 11 wherein the tissue to be treated comprises brain tissue.