COMPOSITE MESH DEVICES AND METHODS FOR SOFT TISSUE REPAIR

• US 20100318108A1
• Filed: 02/02/2010
• Published: 12/16/2010
• Est. Priority Date: 02/02/2009
• Status: Abandoned Application

• Current Assignee: Biomerix Corp.
• Original Assignee: Biomerix Corp.
• Inventors: Park, Gene, Majmundar, Rujul B., Pearce, Dave, Friedman, Craig, Datta, Arindam, Lavelle, Lawrence P. JR.
• Application Number:
  US12/699,012
• Publication Number:
  US 20100318108A1
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/129 containing macromolecular fillers
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor
• CPC Class Codes: Y10T 156/1092 All laminae planar and face to face
• CPC Class Codes: Y10T 442/10 Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]

Abstract

A composite implantable device for promoting tissue ingrowth therein comprising a biodurable reticulated elastomeric matrix having a three-dimensional porous structure having a continueous network of interconnected and intercommunicating open pores and a support structure is disclosed. The support structure may be a polymeric surgical mesh comprising a plurality of intersecting one-dimensional reinforcement elements, wherein said mesh is affixed to a face of said first matrix. Methods of making and using the implantable device are also provided.

Claims

1. A composite implantable device for promoting tissue ingrowth therein, comprising:

a first biodurable reticulated elastomeric matrix and a second biodurable reticulated elastomeric matrix, said first and second matrices each having a three-dimensional porous structure comprising a continuous network of interconnected and intercommunicating open pores, and

a polymeric surgical mesh comprising a plurality of intersecting one-dimensional reinforcement elements,

wherein said mesh is sandwiched between said first and second matrices and affixed to a face of said first matrix and an opposing face of said second matrix.

2. The composite implantable device of claim 1, wherein said first and second matrices comprises polycarbonate polyurethane or polycarbonate polyurethane-urea.

3. The composite implantable device of claim 2, wherein said first and second matrices are formed from a reaction of a polycarbonate polyol and an isocyanate component comprising a mixture of 2,4′

diphenylmethane diisocyanate and 4,4′

diphenylmethane diisocyanate.

4. The composite implantable device of claim 3, wherein said isocyanate component comprising at least 5% by weight of 2,4′

diphenylmethane diisocyanate.

5. The composite implantable device of claim 1, wherein said mesh comprises an absorbable material.

6. The composite implantable device of claim 5, wherein said mesh comprises at least one selected from the group consisting of a polylactic acid or a poly(lactide ε

-caprolactone).

7. The composite implantable device of claim 1, wherein said mesh is non-resorbable.

8. The composite implantable device of claim 7, wherein said mesh comprises a polyester or a polypropylene.

9. The composite implantable device of claim 1, wherein said plurality of one-dimensional reinforcement elements comprises polypropylene monofilament fibers.

10. The composite implantable device of claim 9, said polypropylene monofilament fibers are knitted to form said mesh.

11. The composite implantable device of claim 1, further comprising a polymeric film coating covering said first matrix or said mesh, wherein said coating reduces adhesion of said device to biologic surfaces.

12. The composite implantable device of claim 1, wherein said polymeric film comprises poly (L-lactide co ε

-caprolactone).

13. The composite implantable device of claim 1, wherein said mesh is bonded to said first matrix by an adhesive.

14. A method for treating a hernia comprising making an incision into an affected area, placing the composite implantable device of claim 1 onto said affected area, and securing said device to said affected area.

15. A method for manufacturing a composite implantable device comprising the steps of:

preparing a first biodurable reticulated elastomeric matrix and a second biodurable reticulated elastomeric matrix, said first and second matrices each having a three-dimensional porous structure comprising a continuous network of interconnected and intercommunicating open pores,

applying an adhesive to a polymeric surgical mesh, wherein said mesh comprises comprising a plurality of intersecting one-dimensional reinforcement elements, and

affixing said mesh to a face of said first matrix and an opposing face of said second matrix such that said mesh is sandwiched between said first and second matrices.

16. A composite implantable device for promoting tissue ingrowth therein, comprising:

a biodurable reticulated elastomeric matrix having a three-dimensional porous structure comprising a continuous network of interconnected and intercommunicating open pores,

a polymeric surgical mesh comprising a plurality of intersecting one-dimensional reinforcement elements, wherein said mesh is affixed to a face of said matrix, and

a polymeric film coating covering said mesh, wherein said coating reduces adhesion of said device to biologic surfaces.

17. A method for treating a hernia comprising making an incision into an affected area, placing the composite implantable device of claim 16 onto said affected area, and securing said device to said affected area.

18. A method for manufacturing a composite implantable device comprising the steps of:

preparing a biodurable reticulated elastomeric matrix having a three-dimensional porous structure comprising a continuous network of interconnected and intercommunicating open pores,

applying an adhesive to a polymeric surgical mesh, wherein said mesh comprises comprising a plurality of intersecting one-dimensional reinforcement elements,

affixing said mesh to a face of said first matrix, and

covering said mesh with a polymeric film, wherein said film reduces adhesion of said device to biologic surfaces.

19. The method of claim 18, wherein said covering step comprises melt-bonding said polymeric film onto said mesh.