Methods and Uses of Anti-IL-23 Antibodies
First Claim
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1. A method for diagnosing or treating an IL-23 related condition in a cell, tissue, organ or animal, comprising:
- contacting or administering a composition comprising an effective amount of an antibody binding to human IL-23p19 at one or more regions of human IL-23p19 consisting of the amino acid residues selected from the group consisting of residues 93-102, 93-110, and 127-137 of SEQ ID NO;
1, with, or to, said cell, tissue, organ or animal.
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Abstract
An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
30 Citations
16 Claims
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1. A method for diagnosing or treating an IL-23 related condition in a cell, tissue, organ or animal, comprising:
contacting or administering a composition comprising an effective amount of an antibody binding to human IL-23p19 at one or more regions of human IL-23p19 consisting of the amino acid residues selected from the group consisting of residues 93-102, 93-110, and 127-137 of SEQ ID NO;
1, with, or to, said cell, tissue, organ or animal.- View Dependent Claims (2, 3, 4, 5)
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6. A method for diagnosing or treating an IL-23 related condition in a cell, tissue, organ or animal, comprising:
contacting or administering a composition comprising an effective amount of an antibody that competitively binds to IL-23p19 with an antibody binding to human IL-23p19 at one or more regions of human IL-23p19 consisting of the amino acid residues selected from the group consisting of residues 93-102, 93-110, and 127-137 of SEQ ID NO;
1, with, or to, said cell, tissue, organ or animal.- View Dependent Claims (7, 8, 9, 10)
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11. A method for diagnosing or treating an IL-23 related condition in a cell, tissue, organ or animal, comprising:
contacting or administering a composition comprising an effective amount of an antibody that competitively binds to IL-23p19 with an isolated IL-23p19 antibody, comprising a light chain variable region and a heavy chain variable region, said light chain variable region comprising; a complementarity determining region light chain 1 (CDRL1) amino acid sequence of SEQ ID NO;
9;a CDRL2 amino acid sequence of SEQ ID NO;
10; anda CDRL3 amino acid sequence of SEQ ID NO;
11, and said heavy chain variable region comprising;a complementarity determining region heavy chain 1 (CDRH1) amino acid sequence of SEQ ID NO;
4;a CDRH2 amino acid sequence of SEQ ID NO;
5; anda CDRH3 amino acid sequence of SEQ ID NO;
6, with, or to, said cell, tissue, organ or animal.- View Dependent Claims (12, 13, 14, 15)
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16. Any invention described herein.
Specification