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Tri- or Tetraspecific Antibodies

  • US 20100322935A1
  • Filed: 05/27/2010
  • Published: 12/23/2010
  • Est. Priority Date: 05/27/2009
  • Status: Active Grant
First Claim
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1. A trispecific or tetraspecific antibody, comprising:

  • a) a light chain and heavy chain of a full length antibody which specifically binds to a first antigen; and

    b) a modified light chain and modified heavy chain of a full length antibody which specifically binds to a second antigen, wherein the variable domains VL and VH are replaced by each other, and/or wherein the constant domains CL and CH1 are replaced by each other; and

    c) one to four antigen binding peptides fused via a peptide connector to the C- or N-terminus of the light chains or heavy chains of a) and/or b) wherein said antigen binding peptides specifically bind one or two further antigens.

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