DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS
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Abstract
The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer.
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18 Claims
- 1. A compound of the formula
- 13. A pharmaceutical composition comprising a compound of the formula
- 16. A method of treating cancer selected from the group consisting of brain cancer, basal cell carcinoma, esophagus cancer, stomach cancer, gastric cancer, pancreatic cancer, biliary tract cancer, prostate cancer, breast cancer, small-cell lung cancer, non-small cell lung cancer, B-cell lymphoma, multiple myeloma, ovarian cancer, colorectal cancer, liver cancer, kidney cancer, melanoma, head and neck cancer, mesothelioma, soft tissue sarcomas, bone sarcomas, leukemia, and testicular cancer in a mammal comprising administering to the mammal an effective amount of a compound of the formula
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