PHYSIOLOGIC SIGNAL MONITORING USING ULTRASOUND SIGNALS FROM IMPLANTED DEVICES

• US 20100324378A1
• Filed: 05/18/2010
• Published: 12/23/2010
• Est. Priority Date: 06/17/2009
• Status: Abandoned Application

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Tran, Binh C., Hatlestad, John D., Peterson, Jon, Ingle, Frank
• Application Number:
  US12/782,369
• Publication Number:
  US 20100324378A1
• Time in Patent Office: Days
• US Class Current: 600/301
• CPC Class Codes: A61B 5/0028 Body tissue as transmission medium, i.e. transmission systems where the medium is the human body
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence

Abstract

Devices, systems, and methods for monitoring and analyzing physiologic parameters within the body using an intrabody ultrasound signal are disclosed. An illustrative method includes receiving an ultrasound signal transmitted from a remote device containing encoded sensor data, converting the ultrasound signal into an electrical signal, decoding the sensor data from the electrical signal and generating a first physiological waveform, generating a second physiological waveform by analyzing fluctuations of the electrical signal caused by physiologic modulation of the ultrasound signal during propagation through the body, and analyzing one or more characteristics of the first and second waveforms to determine one or more physiologic parameters within the body.

Claims

1. A method for determining one or more time-varying physiologic parameters within the body of a patient using intrabody ultrasound signals, comprising:

receiving an ultrasound signal transmitted from a remote device located within the body, the ultrasound signal including encoded sensor data measured by the remote device;

transducing the ultrasound signal into an electrical signal;

decoding the sensor data from the electrical signal and generating a first physiological waveform corresponding to the sensor data measured by the remote device; and

generating a second physiological waveform by analyzing fluctuations of the electrical signal caused by physiologic modulation of the ultrasound signal during propagation through the body.

2. The method of claim 1, further including analyzing at least one characteristic of the first and second physiological waveforms to determine one or more physiological parameters within the body.

3. The method of claim 1, wherein the first physiological waveform is a pressure waveform.

4. The method of claim 3, wherein the second physiological waveform is a respiration waveform.

5. The method of claim 3, wherein the second physiological waveform is a cardiac waveform.

6. The method of claim 1, further comprising using the one or more physiologic parameters to calibrate another device within the body.

7. The method of claim 1, wherein the remote device is a pressure sensor implanted within a pulmonary artery, and wherein the encoded sensor data comprises blood pressure data measured by the remote device within the pulmonary artery.

8. The method of claim 1, wherein generating a second physiological waveform includes filtering the electrical signal with a low-pass or band-pass filter having a bandwidth corresponding to the frequency range of a physiologic signal of interest.

9. The method of claim 2, wherein analyzing at least one characteristic of the first and second physiological waveforms to determine one or more physiologic parameters within the body includes detecting one or more peaks in the electrical signal and correlating the amplitude and timing of the peaks in the electrical signal with the measured sensor data from the first physiological waveform.

10. The method of claim 2, wherein analyzing at least one characteristic of the first and second physiological waveforms includes determining the end expiration stage of the patient'"'"'s respiration cycle.

11. The method of claim 2, wherein analyzing at least one characteristic of the first and second physiological waveforms includes determining a respiration rate of the patient'"'"'s respiration cycle.

12. The method of claim 2, wherein analyzing at least one characteristic of the first and second physiological waveforms includes determining a tidal volume of the patient'"'"'s respiration cycle.

13. The method of claim 2, wherein analyzing at least one characteristic of the first and second physiological waveforms includes determining a heart rate.

14. The method of claim 2, wherein analyzing at least one characteristic of the first and second physiological waveforms includes determining the presence of at least one of a cardiac arrhythmia, extra beat or skipped beat, or aperiodic cardiac event.

15. The method of claim 1, further comprising adjusting at least one operating parameter of the remote device in response to the one or more physiologic parameters.

16. The method of claim 1, further comprising determining one or more device-related parameters of the remote device based at least in part on the amplitude, phase, and/or time delay of a carrier signal component of the received ultrasound signal.

17. The method of claim 16, wherein determining one or more device-related parameters of the remote device includes measuring a Doppler shift in the received ultrasonic signal.

18. The method of claim 16, further comprising prompting the remote device to transmit a first ultrasound signal at a first frequency and a second ultrasonic signal at a second frequency different than the first frequency, and wherein determining one or more device-related parameters includes measuring a separation distance between the remote device and a communicating device in acoustic communication with the remote device based on a measured change in attenuation of the first and second ultrasound signals received by the communicating device.

19. A method for determining one or more time-varying physiologic parameters within the body of a patient using intrabody ultrasound signals, comprising:

transmitting an ultrasound signal from a remote device located within the body to a communicating device in acoustic communication with the remote device;

receiving the ultrasound signal on an ultrasonic transducer of the communicating device and transducing the ultrasound signal into an electrical signal;

generating a physiological waveform by analyzing fluctuations of the electrical signal caused by physiologic modulation of the ultrasound signal during propagation through the body; and

analyzing the physiological waveform to determine one or more physiologic parameters within the body.

20. A system for determining one or more physiologic parameters within the body of a patient using an intrabody ultrasound signal, comprising;

a remote device including at least one ultrasound transducer adapted to transmit an intrabody ultrasound signal;

a communicating device in acoustic communication with the remote device, the communicating device including at least one ultrasound transducer configured to receive the ultrasound signal and transduce the ultrasound signal into an electrical signal; and

processing means for;

generating a physiological waveform by analyzing fluctuations of the electrical signal caused by physiologic modulation of the ultrasound signal during propagation through the body; and

analyzing at least one characteristic of the physiologic waveform to determine one or more physiologic parameters within the body.

21. The system of claim 20, wherein the physiological waveform is a respiration waveform.

22. The system of claim 20, wherein the physiological waveform is a cardiac waveform.

23. The system of claim 20, wherein the remote device is configured to measure blood pressure within a vessel of the body.

24. The system of claim 23, wherein the ultrasound signal includes encoded pressure data measured by the remote device, and wherein the processing means is further configured for decoding the pressure data from the ultrasound signal and generating a pressure wave corresponding to the pressure data measured by the remote device.

25. The system of claim 20, wherein the processing means is further configured for analyzing at least one characteristic of the physiologic waveform and at least one characteristic of the pressure waveform to determine one or more physiologic parameters within the body.