System for In Vivo Biosensing Based on the Optical Response of Electronic Polymers
First Claim
1. A system for in vivo biosensing of one or more target analyte molecules in a subject, the system comprising:
- at least one implant member configured to be completely implanted in the subject'"'"'s body and to be exposed to the one or more target analyte molecules in the subject'"'"'s body,the implant member including a reflective substrate having deposited thereon at least one polymer and at least one sensitizing agent that causes an oxidation-reduction reaction with the polymer in the presence of the target analyte molecule;
at least one reader member separate from the implant member and configured to be at least temporarily positioned external to the subjects'"'"' body and adjacent to the implant member,the reader member being configured;
i) to emit light having one or more specific wavelengths, and ii) to detect a reflected signal from the implant member; and
at least one data system configured to determine a concentration of the target analyte molecule.
3 Assignments
0 Petitions
Accused Products
Abstract
A system for continuous in vivo biosensing of specific analyte molecule concentrations based on the dynamic optical properties of electronic polymers is disclosed. The biosensor system includes at least one implant member subcutaneously exposed to the interstitial fluid of the subject, and a reader member at least temporarily positioned over the implant member to probe it with light of specific wavelengths through the skin. The system has many potential applications, including the real-time monitoring of blood glucose levels in diabetics as a method to supplement or replace conventional capillary blood testing.
30 Citations
62 Claims
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1. A system for in vivo biosensing of one or more target analyte molecules in a subject, the system comprising:
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at least one implant member configured to be completely implanted in the subject'"'"'s body and to be exposed to the one or more target analyte molecules in the subject'"'"'s body, the implant member including a reflective substrate having deposited thereon at least one polymer and at least one sensitizing agent that causes an oxidation-reduction reaction with the polymer in the presence of the target analyte molecule; at least one reader member separate from the implant member and configured to be at least temporarily positioned external to the subjects'"'"' body and adjacent to the implant member, the reader member being configured;
i) to emit light having one or more specific wavelengths, and ii) to detect a reflected signal from the implant member; andat least one data system configured to determine a concentration of the target analyte molecule. - View Dependent Claims (4, 6, 7, 9, 10, 11, 13, 14, 15, 16, 17, 19, 20, 21, 24, 25, 27, 29, 30, 32, 33, 34, 39)
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40. A method for in vivo biosensing of specific analyte molecule concentrations in a subject, comprising:
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a) completely implanting at least one implant member in the subject'"'"'s body wherein the implant member is exposed to specific analyte molecule concentrations in the subject, the implant including a reflective substrate having deposited thereon at least one polymer and at least one sensitizing agent that causes an oxidation-reduction reaction with the polymer in the presence of the target analyte molecule; b) at least temporarily positioning a reader member external to the subjects'"'"' body and adjacent to the implant member, the reader member emitting light of specific wavelengths and detecting a reflected signal from the implant member; and c) determining a concentration of the target analyte molecule from the reflected signal. - View Dependent Claims (42, 45, 47, 48, 55, 56, 57, 61)
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Specification