Blood Sampling Device Comprising At Least One Filter

• US 20100324449A1
• Filed: 09/26/2008
• Published: 12/23/2010
• Est. Priority Date: 11/02/2007
• Status: Active Grant

• Current Assignee: Commissariat a L'Energie Atomique (AES Corporation)
• Original Assignee: Commissariat a L'Energie Atomique (AES Corporation)
• Inventors: Sollier, Elodie, Pouteau, Patrick, Peponnet, Christine, Rostaing, Hervé
• Granted Patent: US 9,023,292 B2
• Time in Patent Office: Days
• US Class Current: 600/573
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150343 Collection vessels for collecting blood samples from the skin surface, e.g. test tubes, cuvettes sampling from within body cavities A61B5/150015, A61B5/150045
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150419 comprising means for capillary action
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/150969 Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
• CPC Class Codes: A61B 5/150984 Microneedles or microblades
• CPC Class Codes: A61B 5/15105 Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
• CPC Class Codes: A61B 5/15142 Devices intended for single use, i.e. disposable
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

The invention relates to a device for taking blood by capillarity and incorporating a filter and downstream therefrom, an absorbent material for separating a plasma phase of the blood from a cell phase. The device is characterized in that the filter comprises in succession:

• • a prefilter (6) for spreading the blood over the surface of a first membrane (2) having pores of dimension lying in the range 0.1 μm to 5 μm, said membrane having no clumping agent; and
  • said first membrane (2).

Claims

1. A device for sampling blood by capillarity for separating a plasma phase of the blood from a cell phase, the device incorporating a filter and, downstream therefrom, an absorbent material, the device being characterized in that the filter comprises in succession:

a prefilter for spreading the blood over the surface of a first membrane having pores of dimension lying in the range 0.1 μ

m to 5 μ

m, said membrane having no clumping agent; and

said first membrane.

2. A device according to claim 1, characterized in that the dimension of the pores lies in the range 0.5 μ

m to 5 μ

m.

3. A device according to claim 1, characterized in that the density of the pores is such that they occupy 10% to 90% of the surface area of the membrane of the filter.

4. A device according to claim 3, characterized in that the density of the pores is such that they occupy 40% to 80% of the surface area of the membrane.

5. A device according to claim 1, characterized in that prefilter is an absorbent and/or filtering paper that includes fiber.

6. A device according to claim 1, characterized in that the absorbent material is removable.

7. A device according to claim 1, characterized in that the absorbent material is of section greater than that of the filter and presents, outside the outline of the filter, at least one handling zone that may be touched without risk of contaminating the sample that has been taken.

8. A device according to claim 7, characterized in that the absorbent paper presents an outline that is structured by marking, by adhesive, or by compression.

9. A device according to claim 1, characterized in that the volume of the prefilter is dimensioned in such a manner that the absorbent paper is always saturated in plasma.

10. A device according to claim 1, characterized in that it includes a strip support for stiffening the device as a whole.

11. A device according to claim 1, wherein the membrane is dimensioned to cover only part of the surface of the prefilter.

12. A device according to claim 1, characterized in that, in order to take blood, the prefilter includes an end that projects beyond the remainder of the device.

13. A device according to claim 1, characterized in that it includes at least one needle of length L adapted to taking blood from the dermis such that L lies in the range 0.2 mm to 2 mm.

14. A device according to claim 13, characterized in that it includes a matrix of needles of length L distributed over the surface of the filter.

15. A device according to claim 1, characterized in that it includes at least one needle of length L adapted to taking blood from the dermis such that L is substantially equal to 2 mm.

16. A device according to claim 1, characterized in that, in order to take blood, the prefilter includes an end that projects beyond the remainder of the device by about 1 mm.

17. A device according to claim 1, characterized in that it includes a strip support for stiffening the device as a whole, wherein said strip support is hydrophobic and non-absorbent.

18. A device according to claim 1, characterized in that prefilter is an absorbent and/or filtering paper that includes glass fibers.

19. A device according to claim 3, characterized in that the density of the pores is such that they occupy 50% to 80% of the surface area of the membrane.